alexa Temporal Adverse Effects in Leprosy Saudi Patients Receiving Multi Drug Therapy | OMICS International | Abstract
ISSN: 2161-1459

Journal of Clinical & Experimental Pharmacology
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Research Article

Temporal Adverse Effects in Leprosy Saudi Patients Receiving Multi Drug Therapy

Abdulbasit Ibraheem Al-Sieni, Waheed Zaki Al-Layati and Fahad Ahmed Al-Abbasi*

Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

*Corresponding Author:
Fahad Ahmed Al-Abbasi
Department of Biochemistry
Faculty of Science, King Abdul-Aziz University
P. O. Box 50077, Jeddah 21523, Saudi Arabia
Tel: +966559399935
Fax: +96626952288
E-mail: [email protected]

Received date: October 03, 2013; Accepted date: November 11, 2013; Published date: November 18, 2013

Citation: Sieni AIA, Layati WZA, Abbasi FAA (2013) Temporal Adverse Effects in Leprosy Saudi Patients Receiving Multi Drug Therapy. Clin Exp Pharmacol 3:141. doi:10.4172/2161-1459.1000141

Copyright: © 2013 Sieni AIA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background/Purpose: Leprosy or Hansen’s disease is an infectious disease that yet represents major socioeconomic burden to humanity. It results in permanent physical disabilities besides disgraceful social perception to patients. Multi Drug Therapy (MDT) treatment protocol is a combinatorial anti microbial treatments which has been approved by the WHO as the best treatment option for Hansen’s disease. Side effects to MDT protocol are the main limiting obstacle for the treatment course completion that might differ from population to another. Methods: Herein, we are assessing the temporal hematological and biochemical markers of side effects in Saudi leprosy patients treated with MDT protocol for one year. Results: Hematological assessment revealed progressive temporal but mild decline in all the examined parameters (RBC, PCV, Hb, MCH and MCHC) in males and females patients treated with MDT compared to control group. Biochemical assessment for MDT treated leprosy Saudi patients presented mild progressive temporal hepato-renal complications. Patients were fully recovered from all hemato-biochemical adverse effects after 6 months of the MDT treatment completion. Conclusion: MDT was well tolerated in Saudi leprosy patients with mild to moderate temporal hematological and biochemical adverse reactions.

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