alexa Temporo-Parietal Brain Network Impairment Is Related To EEG ALPHA3/ ALPHA2 Frequency Power Ratio in Prodormal Alzheimer ’ s Disease
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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Research Article

Temporo-Parietal Brain Network Impairment Is Related To EEG ALPHA3/ ALPHA2 Frequency Power Ratio in Prodormal Alzheimer ’ s Disease

Moretti D V*, Paternicò D, Binetti G, Zanetti O and Frisoni G B

IRCCS S. Giovanni di Dio Fatebenefratelli, Brescia, Italy

Corresponding Author:
Vito Davide Moretti, MD, PhD
IRCCS Giovanni di Dio Fatebenefratelli
Brescia, Italy
Tel: +390303501597
Fax: +390303533513
E-mail: [email protected]

Received date: July 08, 2013; Accepted date: July 29, 2013; Published date: August 05, 2013

Citation: Moretti DV, Paternicò D, Binetti G, Zanetti O, Frisoni GB (2013) Temporo-Parietal Brain Network Impairment Is Related To EEG ALPHA3/ALPHA2 Power Ration in Prodormal Alzheimer’s Disease. J Neurol Neurophysiol 4:160. doi:10.4172/2155-9562.1000160

Copyright: © 2013 Moretti DV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Reliable biomarkers are the new frontier for an early diagnosis of Alzheimer's disease and to monitor therapeutic options Objective: Volume reduction in temporo-parietal network is associated to mild cognitive impairment (MCI) due to Alzheimer disease (AD). The increase of EEG alpha3/alpha2 ratio has been associated with AD-converter MCI subjects. We investigated the association of alpha3/alpha2 ratio with patterns of cortical thickness in MCI. Methods: 74 adult subjects with MCI underwent clinical and neuropsychological evaluation, electroencephalogram (EEG) recording and high resolution 3D magnetic resonance imaging (MRI). Alpha3/alpha2 power ratio as well as cortical thickness was computed for each subject. Three MCI groups were detected according to increasing tertile values of alpha3/alpha2 and difference of cortical thikness among the groups estimated. Pearson’s r was used to assess the topography of the correlation between cortical thinning and memory impairment. Results: High a3/2 group had total cortical grey matter (CGM) volume reduction of 471 mm2 than Low a3/a2 group (p<.001). High a3/2 group showed a similar but less marked pattern (160 mm2) of cortical thinning when compared to Middle a3/a2 group (p<.001). Moreover, high a3/2 group had wider cortical thinning than other groups, mapped to the Supramarginal and Precuneus bilaterally. No significant cortical thickness difference was found between Middle and Low a3/a2 groups. Conclusion: High EEG alpha3/alpha2 ratio was associated with impairment of temporo-parietal cortical brain in MCI subjects. The combination of EEG alpha3/alpha2 power ratio and cortical thickness measure could be useful for identifying individuals at risk for progression to AD dementia and may be of value in clinical context

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