Ten-year Long-term Endothelial Cell Changes after Iris-fixed Phakic Intraocular Lens Implantation in Korean Patients
|Bong Joon Choi1, Ja Kyun Lee2 and Jong Soo Lee2*|
|1Lee Eye Hospital, Pusan, South Korea|
|2Department of Ophthalmology, School of Medicine, Pusan National University & Medical Research Institute, Pusan National University Hospital, Pusan, South Korea|
|Corresponding Author :||Jong-Soo Lee, MD, PhD.
Department of Ophthalmology, School of Medicine
Pusan National University & Medical Research Institute
Pusan National University Hospital, 1-10 Ami-Dong
Seo-Gu, Pusan 602-739, Republic of Korea
E-mail: [email protected]; [email protected]
|Received July 01, 2014; Accepted August 28, 2014; Published August 30, 2014|
|Citation: Choi BJ, Lee KJ, Lee JS (2014) Ten-year Long-term Endothelial Cell Changes after Iris-fixed Phakic Intraocular Lens Implantation in Korean Patients. J Clin Exp Ophthalmol 5:352. doi: 10.4172/2155-9570.1000352|
|Copyright: © 2014 Choi BJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Background: To investigate quantitative and morphometric endothelial changes in phakic eyes implanted with an iris-fixed phakic intraocular lens in Korean patients during the long term follow up period.
Design: A prospective interventional case series.
Participants: Sixty six eyes of 37 patients undergoing iris-fixed phakic intraocular lens (Artisan, Ophtec B.V., Groningen, The Netherlands) surgery.
Methods: We prospectively examined endothelial cell density, coefficient variations, frequency of hexagons, and endothelial cell loss in 66 phakic eyes implanted with an iris-fixed phakic intraocular lens. The effect of the anterior chamber depth and intraocular lens power were also statistically analyzed between preoperative and postoperative periods.
Main Outcome Measure: endothelial cell density, coefficient variations, frequency of hexagons.
Results: The follow-up period lasted up to 10 years. The preoperative mean ECD was 2853 ± 249 cells/mm2. After postoperative 5 years, there was a significant loss of approximately 3.0% in the endothelial cell density. Eight years after the operation, there was also a significant change in the CV. There was no significant change in the hexagonality during postoperative 10 years. The preoperative anterior chamber depth and diopter of the iris-fixed phakic intraocular lens did not affect the change in the endothelial cell morphology.
Conclusions: This 10 year follow-up study of changes in endothelial cells after the implantation of an iris-fixated phakic intraocular lens showed the cell density significantly decrease first, and then the coefficient of variation in cell size changed sequent, but the hexagonality of cell was not changed from the preoperative corneal morphology. Endothelial specular microscopy examinations during regular intervals during the follow-up period are mandatory.