Terpenoid Derivatives as Potential Trypanocidal AgentsLozano E1, Barrera P1,2, Spina R1 and Sosa MA1,2*
- *Corresponding Author:
- Miguel A. Sosa
Instituto de Histología y Embriología, FCMUNCuyo
E-mail: [email protected]
Received date: April 28, 2016; Accepted date: May 05, 2016; Published date: May 10, 2016
Citation: Lozano E, Barrera P, Spina R, Sosa MA (2016) Terpenoid Derivatives as Potential Trypanocidal Agents. Med chem (Los Angeles) 6:319-321. doi:10.4172/2161-0444.1000363
Copyright: © 2016 Lozano E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In this review we refer to a promising family of molecules in the fight against Chagas disease. Terpene derivatives are abundant in the plant Kingdom and in the last years many compounds have shown important biological activities. Diterpenes and sesquiterpene lactones have shown in vitro and in vivo trypanocidal activity and they emerge as potential antichagasic drugs. These molecules may act on these parasites by multiple mechanisms, as it has been reported. Moreover, given the chemical structure of these compounds it is feasible to modify these molecules by chemical substitution in order to optimize their action against parasites.