Testing of IgG and IgM against Rubella Virus in School Girls and Pregnant Women in Hanoi where an Outbreak had occurredNguyen Van Bang1*, Nguyen Thi Van Anh2, Vu Thi Tuong Van3, Dao Thi Hop4, Nguyen Van Thuong5 and Elizabeth Elliott6
- *Corresponding Author:
- Nguyen Van Bang
Pediatric Department, Hanoi Medical University
No 299 Giap Bat Street, Hoang Mai District, Hanoi, Vietnam
Tel: +84 438641241, +84 903293212
E-mail: [email protected], [email protected]
Received date: April 17, 2014; Accepted date: May 03, 2014; Published date: May 10, 2014
Citation: Van Bang N, Van Anh NT, Tuong Van VT, Thi Hop D, Van Thuong N, et al. (2014) Testing of IgG and IgM against Rubella Virus in School Girls and Pregnant Women in Hanoi where an Outbreak had occurred. Virology & Mycology 3:130. doi:10.4172/2161-0517.1000130
Copyright: © 2014 Nguyen VB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Congenital Rubella Syndrome (CRS) is preventable illness but stays frequent in developing countries where rubella vaccination is not incorporated in national program of vaccination like in Vietnam actually. Aims: This study aimed at obtaining baseline information on acquired immunization status of school girls as well as the rate of susceptibility and rubella infection in pregnant women around a rubella outbreak in Hanoi, Vietnam. Population and methods: During and after the rubella outbreak in 2011, sera from 136 school girls (aged from 14 to 17 years) and 140 pregnant women in Hanoi French hospital were tested for rubella-specific IgG and for rubella-specific IgM (only in pregnant women) by the technique of Electro-Chemiluminescence Immunoassay (ECLIA) (Roche Diagnostics) with cut-off value ≥ 10 IU/mL for IgG and ≥ 0.3 IU/mL for IgM. Results: Rubella-specific IgG antibodies was positive in 125/136 (91.9%) school girls and 119/140 (85%) pregnant women, with strong-to-extreme concentration in 86/136 (63.2%) school girls versus 19/140 (13.6%) in pregnant women (p<0.002). Rubella-specific IgG was negative (susceptible to rubella infection) in 21/140 (15%) and rubella-specific IgM antibodies was positive in 27.9% (39/140) pregnant women, of whom 38 (27.1%) a co-existence of rubella-specific IgG and IgM were documented. Conclusions: This preliminary, baseline per/post epidemic information showed a high rate of acquired immunization in female adolescents but also high rate of susceptibility and very high rate of rubella infection in pregnant women, warranting further comprehensive studies to determine robust, nationwide epidemiological data prior to establishing the national program of immunization against rubella and identify appropriate methods for CRS surveillance in Vietnam.