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ISSN: 2157-7536

Journal of Steroids & Hormonal Science
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Research Article

Testosterone Treatment Improves Insulin Resistance in Japanese Male Metabolic Syndrome

Ueshiba H*

Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan

*Corresponding Author:
Ueshiba H
Department of Internal Medicine
Toho University School of Medicine
Tokyo, Japan
E-mail: [email protected]

Received date: June 01, 2013; Accepted date: July 21, 2013; Published date: July 26, 2013

Citation: Ueshiba H (2013) Testosterone Treatment Improves Insulin Resistance in Japanese Male Metabolic Syndrome. J Steroids Horm Sci 4:116. doi:10.4172/2157-7536.1000116

Copyright: © 2013 Ueshiba H. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The metabolic syndrome involves a cluster of clinical features including visceral obesity, insulin resistance, hypertension, glucose intolerance, and dyslipidemia. Recent studies have shown that low testosterone levels are significantly associated with metabolic syndrome and type 2 diabetes. We examined the change in insulin resistance after testosterone treatment in five Japanese men with metabolic syndrome and low free testosterone levels (age : 50.2 ± 8.7 yrs, BMI : 30.5 ± 5.0, waist : 97 ± 7 cm ; Mean ± SD). Testosterone supplements were administered by intramuscular injection (250 mg every 2 weeks) for 3 to 6 months. Fasting plasma glucose (FPG), fasting serum insulin (F-IRI), HbA1c, total cholesterol(TCHO), triglyceride(TG), HDL-C, LDL-C, free testosterone, LH, FSH, BMI and waist circumference were measured. We used homeostasis model assessment (HOMA-R) as an index of insulin resistance and investigated the change in insulin resistance after testosterone treatment. Average results before treatment were as follows: BMI 30.5 ± 5.0, waist 97 ± 7 cm, FPG 112 ± 6 mg/dl, F-IRI 25.1 ± 8.5 μIU/ml, HOMA-R 7.0 ± 2.7, HbA1c(NGSP) 5.8 ± 0.3%, TCHO 227 ± 31 mg/dl, TG 185 ± 64 mg/dl, HDL-C 43 ± 9 mg/dl, LDL-C 149 ± 37 mg/dl, free testosterone 5.9 ± 1.0 pg/ml, LH 1.7 ± 0.6 IU/ml, FSH 3.7 ± 0.7 IU/ml. After treatment, F-IRI, HOMA-R, TCHO and LDL-C were significantly decreased to 12.9 ± 3.6 μIU/ml, 3.3 ± 1.1 199 ± 29 mg/dl and 120 ± 31 mg/dl, respectively. Free testosterone was significantly increased to 8.5 ± 0.6 pg/ml. Other parameters were not changed significantly. In conclusion, these results suggest that testosterone treatment improves insulin resistance in Japanese men with metabolic syndrome and low free testosterone levels.

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