alexa Tetracycline Resistant Genes in E. coli Isolated from UTI and Diarrhea Patients in Zaria, Nigeria
ISSN: 2327-5073

Clinical Microbiology: Open Access
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Research Article

Tetracycline Resistant Genes in E. coli Isolated from UTI and Diarrhea Patients in Zaria, Nigeria

Igwe JC1*, Musa A2, Olayinka BO3, Ehnimidu JO3 and Onaolapo JA3

1Department of Medical Biotechnology, National Biotechnology Development Agency, Abuja, Nigeria

2Department of Water Sanitation and Hygiene, Dutse Local Government, Jigawa State, Nigeria

3Department of Pharmaceutics and Pharmaceutical Microbiology, Ahmadu Bello University, Zaria, Nigeria

*Corresponding Author:
Igwe JC
Department of Medical Biotechnology
National Biotechnology Development Agency
Abuja, Nigeria
Tel: +234-8069430222
E-mail: igwejames42@yahoo.com

Received Date: October 07, 2015; Accepted Date: December 23, 2015; Published Date: December 30, 2015

Citation: Igwe JC, Musa A, Olayinka BO, Ehnimidu JO, Onaolapo JA (2015) Tetracycline Resistant Genes in E. coli Isolated from UTI and Diarrhea Patients in Zaria, Nigeria. Clin Microbiol 4:225. doi: 10.4172/2327-5073.1000225

Copyright: © Igwe JC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Tetracycline (TC) is one of the widely used antibiotics for the treatment of infections with significant therapeutic effect due to its broad spectrum. But due to the emergence of high percentages of tetracycline resistance and the recent reoccurrence of multidrug resistance isolates in clinical settings, its use in hospitals have drastically reduced. This study evaluates the percentage of TC resistant in clinical isolates of E. coli from UTI and diarrhea patients in Zaria, Nigeria. Out of the 86 E. coli isolates collected from 4 hospitals for the period of 6 months (April-September, 2014), 68.6% (59) were observed to be resistant to TC using both disc diffusion and MIC (range of ≥ 4 μg/ml) methods. The antibiotic susceptibility profile of the isolates showed that the isolates had varied antibiotic resistant profile to the 14 antibiotics tested. Significant percentage (35.6% (21)) of the isolates also exhibited simultaneous resistance to Ciprofloxacin, Gentamicin and Amoxicillin. The isolates were also observed to have high MARI, and there molecular analysis showed that 95% (20) of the MDR isolates had TetA gene while 90.5% (19) had TetB gene. Our results showed that there is a correlation between phenotypic TC resistance and genomic TetA and TetB carriage in E. coli isolates from UTI and diarrhea patients in Zaria, Nigeria.

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