alexa The 7D4, 4C3 and 3B3 (-) Chondroitin Sulphation Motifs are expressed at Sites of Cartilage and Bone Morphogenesis during Foetal Human Knee Joint Development
ISSN: 2168-958X

Journal of Glycobiology
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Research Article

The 7D4, 4C3 and 3B3 (-) Chondroitin Sulphation Motifs are expressed at Sites of Cartilage and Bone Morphogenesis during Foetal Human Knee Joint Development

James Melrose1-3*, Susan M Smith1, Clare E Hughes4, Christopher B Little1,2, Bruce Caterson4 and Anthony J Hayes5

1Raymond Purves Bone and Joint Research Laboratory, Kolling Institute Northern Sydney Local Health District, St. Leonards, New South Wales 2065,Australia

2Sydney Medical School Northern, The University of Sydney, Australia

3Graduate School of Biomedical Engineering, University of New South Wales, Kensington, New South Wales 2052, Australia

4Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Cardiff, CF10 3US, Wales, UK

5Confocal Microscopy Unit, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, Wales, UK

*Corresponding Author:
James Melrose
Raymond Purves Bone and Joint Research Laboratory
Kolling Institute, level 10 (B6)
Royal North Shore Hospital, St. Leonards
New South Wales 2065, Australia
Tel: +61 2 9926 4806
Fax: + 61 2 9926 5266
E-mail: [email protected]

Received Date: July 01, 2016; Accepted Date: July 19, 2016; Published Date: July 26, 2016

Citation: Melrose J, Smith SM, Hughes CE, Little CB, Caterson B, et al. (2016) The 7D4, 4C3 and 3B3 (-) Chondroitin Sulphation Motifs are expressed at Sites of Cartilage and Bone Morphogenesis during Foetal Human Knee Joint Development. J Glycobiol 5:118. doi:10.4172/2168-958X.1000118

Copyright: © 2016 Melrose J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Novel sulphation motifs within the glycosaminoglycan (GAG) chain structure of chondroitin sulphate (CS)- containing s are associated with sites of growth and differentiation in many biological systems where they function as molecular recognition sites involved in the binding, sequestration or presentation of soluble signalling molecules (e.g. growth factors, cytokines, morphogens). The specific sulphation motifs on CS identified by monoclonal antibodies 3-B-3(-), 4-C-3 and 7-D-4 are also associated with distinct cohorts of cells in areas of tissue morphogenesis in human foetal knee joint development. We hypothesize that such motifs may have roles to play in the regulation of proliferative/differentiative events during tissue morphogenesis. In the present investigation we have examined the distribution of these CS motifs within the rudiment cartilage, stromal connective tissues surrounding the rudiment cartilages and developing growth plates of the human foetal knee joint. These CS motifs had broad, overlapping distributions throughout the differentiating connective tissues undergoing morphogenesis and after joint cavitation were localised very specifically to the rudiment cartilage destined to form the permanent articular cartilage postnatally, and to the terminally differentiated chondrocytes and calcified cartilage-bone interface in the growth plate cartilages. The overlapping distributions of these molecules within the presumptive articular cartilage, prior to secondary ossification, suggests that they participate in early signalling events involved in tissue development and indicates that the cells within this zone are phenotypically distinct from those of the underlying rudiment cartilage.

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