alexa The Antioxidant Activity of Peptides Isolated from Amaranthus on Normal Human Skin in vitro and Inflammatory Cytokines Detection
ISSN: 2155-9600

Journal of Nutrition & Food Sciences
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


The Antioxidant Activity of Peptides Isolated from Amaranthus on Normal Human Skin in vitro and Inflammatory Cytokines Detection

Alcántara Quintana LE1*, Ortiz Hernández A2, Rivera María del P3 and Soriano Santos J2

1División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, México

2Departamento de Biotecnología, Universidad Autónoma Metropolitana, Iztapalapa. Av. San Rafael Atlixco 186, Vicentina, Iztapalapa, Cp. 09340, México

3Hospital de Especialidades, Centro Médico Nacional Siglo XXI. IMSS. Av. Cuauhtémoc 330, Col. Doctores, Del. Cuauhtémoc, Cp. 06720. México

*Corresponding Author:
Alcántara Quintana LE
División de Biología Molecular
Instituto Potosino de Investigación Científica y Tecnológica
San Luis Potosí, Camino a la Presa San Jose 2055
Lomas 4a sección. Cp 78216, México
Tel: 524448342000
E-mail: [email protected]; [email protected]

Received date: September 22, 2015; Accepted date: October 29, 2015; Published date: November 02, 2015

Citation: Alcántara Quintana LE, Ortiz Hernández A, Rivera María del P, Soriano Santos J (2015) The Antioxidant Activity of Peptides Isolated from Amaranthus on Normal Human Skin in vitro and Inflammatory Cytokines Detection. J Nutr Food Sci 5:419. doi: 10.4172/2155-9600.1000419

Copyright: © 2015 Alcántara Quintana LE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Oxidative stress has been implicated in various skin diseases through the generation of reactive oxygen species and the depletion of endogenous antioxidant systems. Evidence exists indicating that oxidative stress injury of the skin caused by UVB irradiation is mediated predominantly by reactive oxygen species (ROS) immediately after irradiation and by reactive nitrogen species (RNS) at later points. We investigated the protective effect of peptides (albumin and hydrolysates) isolated from Amaranthus (pA) against UVB irradiation, lipid peroxidation (malondialdehyde, MDA) and endogenous antioxidant defense enzymes such as glutathione peroxidase (GPX), superoxide dismutase (SOD) and catalase (CAT). Supernatant levels of pro-inflammatory and anti-inflammatory cytokines were also investigated. We used human skin organ culture as an in vitro model via 24, 36 and 48 hrs of culture. The pA has a significant protective effect via the inhibition of damaged caused by UVB irradiation. The treatment of skin with pA inhibited the UVB-induced lipid peroxidation. Additionally, this pA-inhibited UVB-induced depletion of antioxidant defense components, such as, CAT, SOD, and GPX, and the final antioxidant treatment also reduced levels of pro-inflammatory cytokines: IL-1beta, IL-12, TNF and INF-gamma. We conclude that pA could be useful in attenuating UVB-induced oxidative stress and mitigating skin diseases in human skin due to antioxidant properties.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version