alexa The Antitumor Potential of Quercetin on Solid Ehrlich T

Cancer Medicine & Anti Cancer Drugs
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Research Article

The Antitumor Potential of Quercetin on Solid Ehrlich Tumor in Female Mice

Elsisy MK*, Ibrahim WM, Salama AF and Kasem SM

Faculty of Science, Tanta University, Egypt

*Corresponding Author:
Dr. Mohammed Khaled Elsisy
Faculty of Science, Tanta University, Egypt
Tel: 00201090848093
E-mail: [email protected]

Received date: June 19, 2017; Accepted date: July 12, 2017; Published date: July 24, 2017

Citation: Elsisy MK, Ibrahim WM, Salama AF, Kasem SM (2017) The Antitumor Potential of Quercetin on Solid Ehrlich Tumor in Female Mice. Cancer Med Anticancer Drug 2:108.

Copyright: © 2017 Elsisy MK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

Background: The unusual accelerated division of group of cells is known as tumor, which may spread out through the body causing what is known as cancer. Quercetin is a well-known flavonoid which is abundant in many plants, and thought to have many therapeutic effects.

Aim of the study: The study performed to evaluate the anti-tumor potential of Quercetin against solid Ehrlich tumor in female mice.

Method: The study was carried out on 5 groups of female mice; Group I (Negative control), group II (Ehrlich tumor only), group III (Ehrlich+Methotrexate), group IV (Ehrlich+Quercetin) and group V (Ehrlich+Methotrexate +Quercetin). Estimation of Quinone Reductase and Aromatase enzymes activities, Malondialdehyde(MDA) concentration, Tumor Volume, percentage of DNA damage and Survivability were detected, in addition to genomic instability via RAPD-PCR.

Results: Under the influence of Quercetin administration to the tumor bearing mice; Quinone Reductase was increased, Aromatase was decreased, MDA was decreased, DNA damage was lowered, and Tumor volume was shrinked, RAPD-PCR showed the nearest pattern of bands to control and survivability was prolonged.

Conclusion: The results proved an anti-tumor potential of Quercetin with a suggestion of co-administration of Quercetin together with Methotrexate as the best choice for cancer treatment.

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