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ISSN: 2167-1044

Journal of Depression and Anxiety
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Research Article

The Association of Cortisol Stress Response with Early Adversity and Diabetes Control in Adolescents with Diabetes

Korczak DJ1*, Madigan S2, Manassis K1 and Daneman D3
1Department of Psychiatry, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario Canada
2Department of Pediatrics, Hospital for Sick Children and University of Toronto, Canada
3Department of Pediatrics, Hospital for Sick Children and University of Toronto
Corresponding Author : Daphne J. Korczak, MD, M.Sc
Assistant Professor, Department of Psychiatry
The University of Toronto, 1145 Burton Wing
The Hospital for Sick Children
555 University Avenue, Toronto
Ontario, Canada, M5G 1X8
Tel: 416-813-8923
Fax: 416-813-5326
E-mail: [email protected]
Received September 21, 2015; Accepted January 24, 2016; Published January 27, 2016
Citation: Korczak DJ, Madigan S, Manassis K, Daneman D (2016) The Association of Cortisol Stress Response with Early Adversity and Diabetes Control in Adolescents with Diabetes. J Depress Anxiety 5:217. doi:10.4172/2167-1044.1000217
Copyright: © 2016 Korczak DJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

1.1 Objectives: The hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the relationship between increased stress and poor diabetes control in children with type 1 diabetes mellitus (T1DM). The objectives of this study were two-fold: (1) To evaluate the effectiveness of the Trier Social Stress Test for Children (TSST-C) in inducing psychosocial stress in children with T1DM; (2) To investigate predictors of the cortisol stress response to the TSST-C. 1.2 Methods: Seventeen adolescents with T1DM were exposed to the TSST-C. Salivary cortisol was sampled pre-TSST-C and at six 10-minute intervals following the stress procedure. Measures of anxiety, depression, family functioning and early adversity were completed. 1.3 Results: The TSST-C induced a significant increase in cortisol response (p<.01). Early adversity predicted cortisol response to the stressor (p=.01). Early adversity was also associated with poorer diabetes control (p=.05). 1.4 Conclusion: The TSST-C was effective in producing a stress response in children with diabetes. Whereas previous research has emphasized psychological pathways which contribute to the relationship between psychosocial stressors and poor diabetes control, this study suggests that biological dysfunction may also underlie the association.

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