alexa The Bioavaliability of Hepatoprotective Flavoniods in Hypericum Japonicum Extract | OMICS International
ISSN: 1948-593X

Journal of Bioanalysis & Biomedicine
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Research Article

The Bioavaliability of Hepatoprotective Flavoniods in Hypericum Japonicum Extract

Ning Wang1, Yonggang Wang1, Peibo Li1, Wei Peng1, Tangning Xie1, Yibin Feng2, Weiwei Su1*

1Guangzhou Quality R&D Center of Traditional Chinese Medicine, School of Life Science, Sun Yat-sen University, Guangzhou, 510275, P.R. China

2School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong

*Corresponding Author:
Dr. Weiwei Su,
Guangzhou Quality R&D Center of Traditional Chinese Medicine
School of Life Science, Sun Yat-sen University
Guangzhou, 510275, P.R. China
E-mail: [email protected]

Received Date: October 18, 2009; Accepted Date: December 26, 2009; Published Date: December 26, 2009

Citation: Wang N, Wang Y, Li P, Peng W, Xie T, et al. (2009) The Bioavaliability of Hepatoprotective Flavoniods in Hypericum Japonicum Extract. J Bioanal Biomed 1:033-038. doi:10.4172/1948-593X.1000007

Copyright: © 2009 Wang N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Purpose: To study the absorption of main flavonoids in Hypericum japonicum extract (HJE) with liver protective property; Method: HPLC-ESI-MS was introduced to identify and evaluate the flavonoids in HJE; Caco-2 cell monolayer model was established and validated, and the compounds in HJE, including quercetin (Q), quercetin-3-Orhamnoside (Q-3-R), quercetin-7-O-rhamnoside (Q-7-R) and quercetin-3-O-glucoside (Q-3-G) were administrated in individual, paired or mixed form of the compounds to the monolayer to evaluate their apparent permeability coefficients (Papp value). The transport of HJE was also investigated, mixture of pure components and HJE Inhibitor was added to investigate the transport mechanism of the compound mixture. The absorption of the four main ingredients in HJE was then investigated in vivo. Result: transportation of Q, Q-3-R Q-3-G but not Q-7-R through Caco-2 monolayer was observed when they were administrated individually. Increase of the transport of Q-3-G and Q-7-R and decrease in Q were observed when the four compounds were given in paired form; when the four flavonoids were given as a whole (either in mixture of pure compounds or in HJE), mass permeability of Q-3-R, Q-7- R and Q-3-G was found. In vivo study identified the in vitro investigation that the major active components of HJE could be absorbed after orally administrated to mice. Conclusion: The increased transport of mixed active components in HJE gives rise to the enhanced hepatoprotetive effect of HJE, and therefore supports the use of botanical drugs.

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