alexa The Biologic Potential of Lyophilized Extracts of Brickellia cavanillesii (Asteraceae): Apoptosis and Glut 2 Gene Expression | OMICS International | Abstract
ISSN: 2157-7110

Journal of Food Processing & Technology
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Research Article

The Biologic Potential of Lyophilized Extracts of Brickellia cavanillesii (Asteraceae): Apoptosis and Glut 2 Gene Expression

Etetor Eshiet R1*, Jinqiu Zhu2 and Ernest Smith E2*

1Sustainable Energy Environmental and Educational Development (SEEED), Sugar land, Texas, USA

2The Institute of Environmental and Human Health, Texas Tech University, Lubbock, Texas, USA

*Corresponding Author:
Etetor Eshiet R
Sustainable Energy Environmental and Educational Development (SEEED)
Sugar land, Texas, USA
Tel: 832-818-8073
E-mail: [email protected]

Ernest Smith E
The Institute of Environmental and Human Health
Texas Tech University, Lubbock, Texas, USA
Tel: 806-885-4567
E-mail: [email protected]

Received date: November 19, 2015; Accepted date: December 14, 2015; Published date: December 23, 2015

Citation: Etetor Eshiet R, Zhu J, Ernest Smith E (2015) The Biologic Potential of Lyophilized Extracts of Brickellia cavanillesii (Asteraceae): Apoptosis and Glut 2 Gene Expression. J Food Process Technol 7:541. doi:10.4172/2157-7110.1000541

Copyright: © 2015 Etetor Eshiet R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Prior investigations into the therapeutic potential of Lyophilized extracts of Brickellia cavanillesii (LBC) are indicative of its possible biologic benefit in the treatment of type 2 diabetes mellitus (T2DB). This manuscript employs in vitro toxicological techniques to explore the effect of LBC on the gene expression of human carcinoma liver cells (HepG2); and attempts to predict a mechanism of action using apoptosis as a therapeutic index. The effect of LBC on the expression of genes associated with human apoptosis pathway and glucose transporter 2 (GLUT 2) were determined using quantitative gene array and real-time PCR (RT2qPCR) respectively. HepG2 cells were exposed to concentrations of LBC (0 mg/mL [control]), 0.2 mg/mL for the apoptosis study; 0 mg/mL (control), 0.02 mg/mL, 0.2 mg/mL for the GLUT 2 study), in the absence of FBS 2 h, 4 h, 6 h and 24 h respectively. Results obtained show that several antiapoptotic genes were significantly up-regulated while some apoptotic genes were significantly down-regulated. The most significant up-regulation was by BCL2L1 with a fold change of 46.57; Bcl2l is reputed to be an apoptosis inhibitor. Data acquired from the GLUT 2 gene expression study suggest that LBC may induce GLUT 2 gene expression.

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