The BTBR T+tf/J (BTBR) Mouse Model of AutismKathryn K. Chadman* and Sara R. Guariglia
Behavioral Pharmacology Laboratory, Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
- *Corresponding Author:
- Kathryn K. Chadman
Behavioral Pharmacology Laboratory
Department of Developmental Neurobiology
New York State Institute for Basic Research in Developmental Disabilities
1050 Forest Hill Road, Staten Island, NY 10314, USA
E-mail: [email protected]
Received date: September 10, 2012; Accepted date: November 16, 2012; Published date: November 19, 2012
Citation: Chadman KK, Guariglia SR (2012) The BTBR T+tf/J (BTBR) Mouse Model of Autism. Autism S1:009. doi:10.4172/2165-7890.S1-009
Copyright: © 2012 Chadman KK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Mouse models of neuropsychiatric disorders are validated according to three different criteria: face validity, construct validity and predictive validity. Autism Spectrum Disorders (ASDs) are diagnosed behaviorally, therefore, mouse models of ASDs rely primarily on face validity. The three diagnostic criteria for ASDs are impairments in social interaction, communication and repetitive behavior, and/or restricted interests. The BTBR T+tf/J (BTBR) mice are an inbred strain used as model of ASDs. All three types of behavioral criteria have been evaluated in the BTBR mice. An advantage of using an inbred strain, such as BTBR is that, the mice are considered genetically identical and offer good controls for experimentation. The BTBR mice have demonstrated face validity for the three core behaviors that define ASDs. Low levels of social behavior, altered communication and spontaneous grooming comprise the behavioral phenotype of the BTBR mice. For construct validity, the BTBR mice have some physiological
characteristics similar to humans with ASDs. Several drug and behavioral treatments for ASDs have been examined in the BTBR mice; however this area of research is still being developed. This review will offer a description of the behavior and physiology of the BTBR mice as a model for ASDs.