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ISSN: 2161-0401

Organic Chemistry: Current Research
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Research Article

The Chemistry of Alkenyl Nitriles and its Utility in Heterocyclic Synthesis

Abdel-Sattar S Hamad Elgazwy* and Mahmoud R Mahmoud Refaee
Department of Chemistry Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
Corresponding Author : Abdel-Sattar S. Hamad Elgazwy
Department of Chemistry Faculty of Science
Ain Shams University, Abbassia 11566, Cairo, Egypt
E-mail: [email protected]
Received April 26, 2013; Accepted June 25, 2013; Published June 28, 2013
Citation: Elgazwy ASSH, Refaee MRM (2013) The Chemistry of Alkenyl Nitriles and its Utility in Heterocyclic Synthesis. Organic Chem Curr Res 2:117. doi:10.4172/2161-0401.1000117
Copyright: © 2013 Elgazwy ASSH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

This review deals with the synthesis involving alkenyl nitriles of heterocyclic systems arranged by increasing ring size and the heteroatoms. Reagents containing alkenyl nitriles and aryl nitriles centers are very important in organic synthesis since they can be versatile and effective species for the efficient construction of rather complex structures from relatively simple starting materials. These reagents have proven to be valuable tools in the synthesis of a wide variety of molecular heterocyclic systems. Their importance stems from the facile bond formation at cyanide centers which can react selectively under suitable conditions. The aim of this review is the analysis and comparison of the various models having evolved on the basis of alkenyl nitriles and their application toward stereoselective synthesis.

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