The Clinical Value of Copeptin in Acute Coronary Syndrome
|Nora M Aborehab1*, Tarek M Salman2, Ola S Mohamed3, Abdel Rahman H El Boquiry4 and Manal A Mohamed5|
|1Assistant lecturer in Biochemistry Department, Faculty of Pharmacy, MSA University, Egypt|
|2Professor of Biochemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt|
|3Professor, Head of Biochemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, Egypt|
|4Cardiology Consultant, National Heart Institute, Giza, Egypt|
|5Fellow of Medical Biochemistry, National Heart Institute, Giza, Egypt|
|Corresponding Author :||Nora M Aborehab
Assistant lecturer in Biochemistry Department
Faculty of Pharmacy, MSA University, 1633
1st district, neighboring 8, 6-october, Giza, Egypt
E-mail: [email protected]
|Received November 05, 2013; Accepted December 07, 2013; Published December 12, 2013|
|Citation: Aborehab NM, Salman TM, Mohamed OS, Boquiry ARHE, Mohamed MA (2013) The Clinical Value of Copeptin in Acute Coronary Syndrome. J Clin Exp Cardiolog 4:278. doi:10.4172/2155-9880.1000278|
|Copyright: © 2013 Aborehab NM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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(1) The introduction of a novel immunoassay measuring copeptin, the c-terminal part of the vasopressin prohormone provided a unique window in common medical disorder. We examined the ability of copeptin in combination with cardiac troponin-I (cTn-I) in diagnosis of AMI, the differentiation between AMI and UA and finally evaluate the ability of copeptin in enhancing sensitivity of cTn-I at early hours of admission in emergency department.
(2) This study was carried on 50 subjects; they were divided into 33 patients with AMI and 17 patients with UA. Concentrations of copeptin, cTn-I and CK-MB were determined in their sera.
(3) In AMI group, the mean serum level of copeptin was highly significant in three hours than admission time and six hours. The mean serum level of cTn-I was highly significant in six hours than the admission time and three hours. The sensitivity and specificity of copeptin and cTn-I combination were 100% and 100% at the admission time versus 72.7% and 82.4% with cTn-I alone also versus 97% and 94.1% with combination of cTn-I and CK-MB. The AUC of the combination of copeptin and cTn-I was 1 which was significantly higher than the AUC of cTn-I alone 0.81 and the AUC of combination of cTn-I and CK-MB 0.92
(4) Copeptin as a single marker has diagnostic value being superior to cTn-I within the first three hours after acute chest pain. Dual marker strategy combining cTn-I and copeptin show incremental value in the early rule out of AMI.