alexa The Complex Role of Leptin in SLE: Is Leptin A Key Link between Metabolic Syndrome, Accelerated Atherosclerosis and Autoimmunity? | OMICS International| Abstract

Lupus: Open Access

  • Review Article   
  • Lupus Open Access 2016, Vol 1(1): 107

The Complex Role of Leptin in SLE: Is Leptin A Key Link between Metabolic Syndrome, Accelerated Atherosclerosis and Autoimmunity?

Domenico PE Margiotta*, Marta Vadacca, Luca Navarini, Fabio Basta and Antonella Afeltra
Unit of Allergology, Immunology, Rheumatology, Department of Medicine, Universita Campus Bio-Medico di Roma, Rome, Italy
*Corresponding Author : Domenico PE Margiotta, Unit of Allergology, Immunology, Rheumatology, Department of Medicine, Universita Campus Bio-Medico di Roma, Italy, Tel: +39 06 22541 1289, Fax: +39 06 225412 1980, Email: [email protected]

Received Date: Jan 01, 2016 / Accepted Date: Jan 25, 2016 / Published Date: Feb 11, 2016

Abstract

Adipokines discovery opened a new research field that investigates the interface and the relationship between immune response, nutrition, and metabolism. Leptin is the first adipokine discovered and exerts a wide spectrum of biologic function such as control of food intake and energy expenditure, modulation of insulin sensitivity, regulation of neuro-endocrine system and activation of immunity. Leptin involvement is described in many autoimmune diseases. In SLE, leptin seems playing a complex role, linking metabolic syndrome, atherosclerosis, and autoimmune disease activity.

Keywords: Leptin; SLE; Metabolic syndrome; Atherosclerosis

Citation: Margiotta DPE, Vadacca M, Navarini L, Basta F, Afeltra A (2016) The Complex Role of Leptin in SLE: Is Leptin A Key Link Between Metabolic Syndrome, Accelerated Atherosclerosis and Autoimmunity? Lupus Open Access 1: 107.

Copyright: © 2016 Margiotta DPE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment
Share This Article
Recommended Conferences
Article Usage
  • Total views: 8729
  • [From(publication date): 2-2016 - Feb 23, 2018]
  • Breakdown by view type
  • HTML page views: 8636
  • PDF downloads: 93