The Complex Role of Leptin in SLE: Is Leptin A Key Link between Metabolic Syndrome, Accelerated Atherosclerosis and Autoimmunity?
Received Date: Jan 01, 2016 / Accepted Date: Jan 25, 2016 / Published Date: Feb 11, 2016
Adipokines discovery opened a new research field that investigates the interface and the relationship between immune response, nutrition, and metabolism. Leptin is the first adipokine discovered and exerts a wide spectrum of biologic function such as control of food intake and energy expenditure, modulation of insulin sensitivity, regulation of neuro-endocrine system and activation of immunity. Leptin involvement is described in many autoimmune diseases. In SLE, leptin seems playing a complex role, linking metabolic syndrome, atherosclerosis, and autoimmune disease activity.
Keywords: Leptin; SLE; Metabolic syndrome; Atherosclerosis
Citation: Margiotta DPE, Vadacca M, Navarini L, Basta F, Afeltra A (2016) The Complex Role of Leptin in SLE: Is Leptin A Key Link Between Metabolic Syndrome, Accelerated Atherosclerosis and Autoimmunity? Lupus Open Access 1: 107.
Copyright: © 2016 Margiotta DPE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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