alexa The Complex Role of Leptin in SLE: Is Leptin A Key Link

Lupus: Open Access
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Review Article

The Complex Role of Leptin in SLE: Is Leptin A Key Link Between Metabolic Syndrome, Accelerated Atherosclerosis and Autoimmunity?

Domenico PE Margiotta*, Marta Vadacca, Luca Navarini, Fabio Basta and Antonella Afeltra

Unit of Allergology, Immunology, Rheumatology, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy

*Corresponding Author:
Domenico PE Margiotta
Unit of Allergology, Immunology
Rheumatology, Department of Medicine
Università Campus Bio-Medico di Roma, Italy
Phone: +39 06 22541 1289
Fax: +39 06 225412 1980
E-mail: [email protected]

Received date: January 01, 2016; Accepted date: January 25, 2016; Published date: January 27, 2016

Citation: Margiotta DPE, Vadacca M, Navarini L, Basta F, Afeltra A (2016) The Complex Role of Leptin in SLE: Is Leptin A Key Link Between Metabolic Syndrome, Accelerated Atherosclerosis and Autoimmunity?. Lupus Open Access 1:107.

Copyright: © 2016 Margiotta DPE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.



Adipokines discovery opened a new research field that investigates the interface and the relationship between immune response, nutrition, and metabolism. Leptin is the first adipokine discovered and exerts a wide spectrum of biologic function such as control of food intake and energy expenditure, modulation of insulin sensitivity, regulation of neuro-endocrine system and activation of immunity. Leptin involvement is described in many autoimmune diseases. In SLE, leptin seems playing a complex role, linking metabolic syndrome, atherosclerosis, and autoimmune disease activity.


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