alexa The Conjugative Transfer of the Multiresistance Gene Between Bacteria is Significantly Promoted by Nano-Alumina | OMICS International
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
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Research Article

The Conjugative Transfer of the Multiresistance Gene Between Bacteria is Significantly Promoted by Nano-Alumina

Zhigang Qiu1, Dong Yang1, Min Jin1, Liangping Hu2, Zhaoli Chen1, Zhiqiang Shen1, Jingfeng Wang1, Xinwei Wang1, Bin Zhang1, Sha Liu1, Yunmei Yu1 and Jun-Wen Li1*

1Institute of Health and Environmental Medicine, Key Laboratory of Risk Assessment and Control for Environment & Food Safety, No.1, Dali Road, Tianjin, 300050, China

2Consulting Center of Biomedical Statistics, No. 27, Taiping Road, Beijing, 100850, China

*Corresponding Author:
Jun-Wen Li
Department of Environment and Health
Institute of Health and Environmental Medicine
No.1, Dali Road, Tianjin, 300050, China
Tel: 86-22-84655345
Fax: 86-22-23328809
E-mail: [email protected]

Received Date: August 01, 2012; Accepted Date: November 28, 2012; Published Date: December 01, 2012

Citation: Qiu Z, Yang D, Jin M, Hu L, Chen Z, et al. (2012) The Conjugative Transfer of the Multiresistance Gene Between Bacteria is Significantly Promoted by Nano-Alumina. J Nanomed Nanotechol 3:154. doi:10.4172/2157-7439.1000154

Copyright: © 2012 Qiu Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Recently, the potential risks of nanomaterials and the spread of antibiotic resistance have become two important environmental concerns. The conjugative transfer of antibiotic resistance genes between bacteria is the most important pathway for the acquisition of antibiotic resistance by bacteria. Both environmental and genetic factors influence the conjugative transfer of antibiotic resistance genes in bacterial populations. The extent to which nanomaterials are able to bring about an increase in antibiotic resistance by regulating the conjugative transfer of antibiotic resistance genes in bacteria is still unknown. In this paper, an Orthogonal Design L64 (421) was used in duplicate to evaluate the effects of bacterial concentration, nano-alumina concentration, mating time, mating temperature and the interactions of those factors on the conjugation transfer in LB broth. The mechanisms by which nano-alumina promote the horizontal transfer of antibiotic multiresistance features were explored by morphological, biochemical, and molecular biological methods. We have shown that nano-alumina promotes the horizontal conjugative transfer multiresistance genes mediated by RP4 up to 250-fold in LB broth and 100-fold in PBS. And it would appear that the effect of promoting conjugative transfer of nano-alumina exceeds the effects of mating temperature and mating time. We also explored the mechanisms behind this phenomenon and demonstrated that nano-alumina is able to induce oxidative stress, cause the damage of bacterial cell membranes, enhance the transcriptional activity of conjugative genes and depress the global regulatory factor genes expression. The findings in this study support the notion that nano-alumina in the environment could result in ecological hazards. More important, an enhanced rate of plasmid transfer among micro-organisms may have an enormous impact on human health and environmental safety.

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