alexa The Contrast of Efficacy and Safety between Carbamazepine and Other Antiepileptic Drugs in Patients with Postencephalitic Epilepsy: Experience from a Developing Country
ISSN: 2168-975X

Brain Disorders & Therapy
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Research Article

The Contrast of Efficacy and Safety between Carbamazepine and Other Antiepileptic Drugs in Patients with Postencephalitic Epilepsy: Experience from a Developing Country

Ying-Ying Li1, Zhi-Hui Zhoua2, Xue-Feng Wang1, Nong Xiao 4, Yang-Mei Chen3, Wenfeng Song5 and Yong Yana Zheng Xiao1*
1Department of Neurology, the First Affiliated Hospital, Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing 400016, China
2Department of Critical Care Medicine, the third People Hospital of Chongqing, China
3Department of Neurology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
4Rehabilitation center, the Children’s Hospital of Chongqing Medical University, China, Chongqing, China
5Department of Health Statistics, School of Public Health, Chongqing Medical University
Corresponding Author : Yong Yana Zheng Xiao
Department of Neurology
The First Affiliated Hospital Chongqing Medical University
Chongqing Key Laboratory of Neurology, Chongqing, China
Tel: 8623-89012903, 8623-67126000
Fax: 8623-68811487
E-mail: [email protected]
Received April 22, 2014; Accepted May 20, 2014; Published May 26, 2014
Citation: Li YY,Zhoua ZH, Wang XF, Xiao N, Chen YM (2014) The Contrast of Efficacy and Safety between Carbamazepine and Other Antiepileptic Drugs in Patients with Postencephalitic Epilepsy: Experience from a Developing Country. Brain Disord Ther 3:125. doi:10.4172/2168-975X.1000125
Copyright: © 2014 Li YY, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Background: Viral encephalitis may cause potentially devastating sequelae, including post-encephalitic epilepsy (PEE) and refractory epilepsy. The purpose of this study was to analyze the efficacy and safety of several antiepileptic drugs (AEDs) in PEE. Methods: A cohort of patients diagnosed with PEE related to presumed encephalitis was retrospectively studied. Patients were divided into different antiepileptic drug groups. Retention rates, 50% responder rates, remission rates and adverse events were evaluated. Several risk factors for adverse events were assessed, including gender, age and drug choice. Results: Two hundred and ninety-two patients were enrolled in this study. PEE manifestations occurred mainly in children. Secondary generalized tonic-clonic seizure (SGTCS) was the frequent type in PEE patients. In the first year, in descending order, the retention rates: Carbamazepine (CBZ) > Topiramate(TPM) Phenobarbital(PB) > Sodium Valproate (VPA-Na) Combined > Magnesium Valproate (VPA-Mg) (P < 0.05, CBZ’s was higher than VPAMg’s and Combined therapy’s), the 50% responder rates were: PB > VPA-Mg > VPANa > TPM > CBZ > Combined (P < 0.05, PB’s and VPA-Mg’s are higher than Combined therapy), the remission rates: VPA-Mg > TPM > CBZ > PB > VPA-Na > Phenytoin Sodium (PHT) > Combined (P < 0.05, TPM’s and VPA-Mg’s are higher than combined therapy’s). In decreasing order, the rates for serious adverse effects were: PHT > TPM > CBZ > PB > VPA-Na > Combined > VPA-Mg. Conclusions: Considering the retention rates, remission rates, 50% responder rates and adverse effects together, we suggest that, compared to CBZ, TPM and VPA-Na should be the good alternatives for PEE patients. When considering the cost together, PB should be another choice in PEE. It is worthy to enlarge the sample size of VPA-Mg to further confirm its good efficacy and safety. And PHT was not recommended for PEE patients.

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