alexa The Contribution of Next Generation Sequencing Technologies to Epigenome Research of Stem Cell and Tumorigenesis | OMICS International | Abstract
ISSN: 2161-0436

Human Genetics & Embryology
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Research Article

The Contribution of Next Generation Sequencing Technologies to Epigenome Research of Stem Cell and Tumorigenesis

Jun Li1, Tingting Wang2, Xiuge Zhang3 and Xu Yang*
Department of Human Medical Research,Research & Cooperation Division, BGI-Shenzhen, Shenzhen 518083,China
Corresponding Author : Xu Yang Ph.D
BGI-Shenzhen, Shenzhen 518083, China
E-mail: [email protected]
Received November 01, 2011; Accepted November 28, 2011; Published November 30, 2011
Citation: Li J, Wang T, Zhang X, Yang X (2011) The Contribution of Next Generation Sequencing Technologies to Epigenome Research of Stem Cell and Tumorigenesis . Human Genet Embryol S2:001. doi: 10.4172/2161-0436.S2-001
Copyright: © 2011 Li J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Epigenome contains another layer of genetic information, not as stable as genome. Dynamic epigenome can serve as an interface to explain the role of environmental factors. Stem cell and tumorigenesis are reported to be closely associated with epigenome modifications. Next generation sequencing (NGS) technologies have directly leaded to the recent advances in epigenome research of stem cell and cancer. DNA methylation and histone modification are two major epigenetic modifications. Four NGS-based approaches have been developed to identify these two epigenetic modifications, including whole genome bisulfite sequencing (WGBS), methylated DNA Immunoprecipitation Sequencing (MeDIP-Seq), reduced representation bisulfite sequencing (RRBS) and chromatin immunoprecipitation sequencing (ChIP-Seq). This paper reviews the recent advances of WGBS, MeDIP-Seq and RRBS for DNA methylation and ChIP-Seq for histone modification in the field of stem cell. The potential contribution of epigenetic modifications to tumorigenesis is also described. At present, the epigenome research still faces the defects of current sampling strategy and unknown network regulation pattern. In future, worldwide collaboration and latest sequencing technologies application are expected to solve these problem and offer new insight into epigenome research.

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