alexa The Cooperative Anticancer Effect of Dual Styrenemaleic
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

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Research Article

The Cooperative Anticancer Effect of Dual Styrenemaleic Acid Nano- Miceller System against Pancreatic Cancer

Khaled Greish1,2,3*, Katherine Muller4, Julie IvanaJay2 and Don Haeng Lee2

1Department of Pharmacology & Toxicology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand

2Utah-Inha DDS & Advanced Therapeutics Research Center, Incheon, South Korea

3Faculty of Medicine, Suez Canal University, Egypt

4Faculty of Pharmaceutical Technology at Philipps-Universität, Marburg, Germany

*Corresponding Author:
Dr. Khaled Greish
Adams building
18 Frederick street
level 2 room 238
Tel: + 64- 3- 479- 4095
Fax: +64 -3-479-9140
Email: khaled. [email protected]

Received Date: September 20, 2011; Accepted Date: November 01, 2011; Published Date: November 03, 2011

Citation: Greish K, Muller K, IvanaJay J, Lee DH (2011) The Cooperative Anticancer Effect of Dual Styrenemaleic Acid Nano-Miceller System against Pancreatic Cancer. J Nanomedic Nanotechnol S4:004. doi:10.4172/2157-7439.S4-004

Copyright: © 2011 Greish K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Pancreatic tumors remain one of the most formidable cancer types to treat. Patients with locally advanced or metastatic disease, which collectively represent over 80% of patients, rarely survive beyond one year. Pancreatic cancer is especially difficult to treat because of the uniqueness of its histology, with few vasculatures that can be used to supply anticancer agents. In this work we test a new system made of two styrene maleic acid (SMA) Nanomiceles encapsulating the phototosensetizer Zinc Protoporphyrin (ZnPP) or anticancer agent 4’-O-tetrahydropyranyl - doxorubicin (THP/Pirarubicin). Our hypothesis is that, local inflammatory response in tumor vessels induced by photosensitization can improve anticancer drug delivery and hence the anticancer activity. Two pancreatic tumor cell lines (Panc-1 and ASPC-1) were used to test the synergism of cytotoxic effect vitro. PANC-1 animal model in SCID mice were utilized to test the anticancer effect and the safety of the dual system in vivo . The photosensitizer activity of ZnPP nanomicelles followed by light irradiation and the administration of the anticancer micelles resulted in a synergetic antitumor effect in SCID mice in vivo but not in vitro . In conclusion, the dual Nanosystem of a photosensitizer and anticancer agent were well tolerated in animal model of pancreatic cancer and resulted in a synergistic anticancer effect. To our knowledge this is the first report of using a dual nanosystem of a photosensitizer and anticancer agent to treat pancreatic cancer.

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