alexa The Correlation between Fetal Fibronectin, Bacterial Vaginosis and Cervical Length in Prediction of Preterm Labour
ISSN: 2376-127X

Journal of Pregnancy and Child Health
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Research Article

The Correlation between Fetal Fibronectin, Bacterial Vaginosis and Cervical Length in Prediction of Preterm Labour

Ahmed Ibrahim Elkhadary1, Emad El-Temamy1*, Ehab Mohamed Hasanen1, Ehab Elhelw2, Ahmed Gamal Eldin Abou El Serour3 and Nabil Fathi Esmael4

1Department of Obstetrics and Gynecology, Al-Azhar University, Cairo, Egypt

2Department of Obstetrics and Gynecology, Al-Azhar University, Dommiate, Egypt

3International Islamic Center for Population Studies and Research, Egypt

4Department of Clinical Pathology, Al-Azhar University, Cairo, Egypt

*Corresponding Author:
Emad El-Temamy
Department of Obstetrics and Gynecology
Al-Azhar University, Cairo, Egypt
Tel: +201001574386
E-mail: [email protected]

Received date: April 04, 2017; Accepted date: April 14, 2017; Published date: April 18, 2017

Citation: Elkhadary AI, El-Temamy E, Hasanen EM, Elhelw E, El-Serour AGEA, et al. (2017) The Correlation between Fetal Fibronectin, Bacterial Vaginosis and Cervical Length in Prediction of Preterm Labour. J Preg Child Health 4:315. doi:10.4172/2376-127X.1000315

Copyright: © 2017 Elkhadary AI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objective: To evaluate the diagnostic value of the cervical length (CL), fetal fibronectin (fFN) in the cervicovaginal secretion and Bacterial vaginosis (BV) infection in prediction of labor in women with threatened preterm labor (TPTL). Patients and methods: One hundred women (100) with TPTL included in this prospective study, which conducted in AL-AZHAR University, department of obstetrics and gynecology after approval of the study by the institute ethical committee and after informed consent. Women included in the study subjected to through history, general and abdominal examinations followed by collection of cervico-vaginal fluid sample for fFN assay, vaginal swab for detection of BV and TVS assessment of the cervical length. Collected data regarding, the cervical length, fFN and BV statistically analyzed to evaluate the diagnostic value of the cervical length, fFN and BV in prediction of labor in women with TPTL. Results: fFN had 86.6% sensitivity, 55.5% specificity, 52% PPV, 88.2% NPV and 64.2% accuracy for detection of labor within one week and the CL measured by TVS had 94.4% sensitivity, 77.7% specificity, 73.9% PPV, 95.4% NPV and 48.4% accuracy for detection of PTL within one week. Sensitivity, positive and negative predictive values were higher for the CL than fFN for detection of PTL within one week. However, the accuracy was better for fFN than the cervical length measured by TVS (64.2% versus 48.4%). Conclusion: fFN concentration in the cervico-vaginal secretion and CL measured by TVS were good predictors for PTL in women with TPTL. The CL at 25 mm cut-off between 28 and 35 weeks gestation had high sensitivity, high positive and negative predictive values than fFN in prediction of PTL, while the fFN was more accurate than the CL.

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