The Critical Role of Calpain in Cell ProliferationLaszlo Kovacs and Yunchao Su*
Department of Pharmacology and Toxicology, Medical College of Georgia,Georgia Regents University, Augusta, GA 30912, USA
- *Corresponding Author:
- Yunchao Su, M.D, Ph.D.
Department of Pharmacology and Toxicology
Medical College of Georgia
Georgia Regents University
1120 15th Street, Augusta, GA 30912, USA
E-mail: [email protected]
Received date: January 03, 2014; Accepted date: February 25, 2014; Published date: March 04, 2014
Citation: Kovacs L, Su Y (2014) The Critical Role of Calpain in Cell Proliferations. J Biomol Res Ther 3:112. doi: 10.4172/2167-7956.1000112
Copyright: © 2014 Kovacs L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Calpain is a conserved family of calcium-dependent, cytosolic, neutral cysteine proteases. The best characterized members of the family are the ubiquitously expressed calpain 1 and calpain 2. They perform controlled proteolysis of their target proteins. The regulation of these enzymes includes autolysis, calcium, phosphorylation as a posttranslational modification, and binding of calpastatin, phospholipids or activator proteins, respectively. Calpain are implicated in many physiological and pathological processes. They have significant role in the cell proliferation, differentiation and migration in a variety of mammalian cell types, contributing to the development of angiogenesis, vascular remodeling, and cancer. Therefore the knowledge of the precise mechanism of calpain signaling could provide therapeutic approaches in these processes.