alexa The Current Role of Bone Marrow Transplantation in the Treatment of Hemophilia A
ISSN: 2329-8790

Journal of Hematology & Thromboembolic Diseases
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Review Article

The Current Role of Bone Marrow Transplantation in the Treatment of Hemophilia A

Hassan Mansouritorghabeh1* and Ali Ghasemi2
1Allergy Research Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Corresponding Author : Hassan Mansouritorghabeh
Allergy Research Center, Ghaem Hospital
School of Medicine, Mashhad University of Medical Sciences
Mashhad, Iran
Tel: +98-511-8012827
Fax: +98-511-8422544
E-mail: [email protected]
Received May 23, 2014; Accepted June 07, 2014; Published June 18, 2014
Citation: Mansouritorghabeh H, Ghasemi A (2014) The Current Role of Bone Marrow Transplantation in the Treatment of Hemophilia A. J Hematol Thrombo Dis 2:143. doi:10.4172/2329-8790.1000143
Copyright: ©2014 Mansouritorghabeh H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Bone marrow transplantation (BMT) is nowadays used in various hematological disorders including leukemias. Hemophilia A is sex linked bleeding disorder in which there are various genetic abnormalities in factor VIII gene. Among various hematological disorders, bleeding disorders mainly hemophilia in now widely treated using plasma derived and recombinant factor VIII concentrates. Day to day transfusion of coagulation factor VIII in current lifelong disorder is a burden for the patients and decreases their quality of life. Although infection of coagulation products with blood-borne viruses that was major concern in treatment of hemophilia has been eliminated nearly complete at the present time, but appearance of factor VIII inhibitor is huge burden in treatment of hemophilia for both clinicians and patients. In this day and age BMT has gathered new insight and acceptable treatment for many hematological and non-hematological disorders. If BMT will be successful in treatment of hemophilia, it will improve quality of life (by nearly permanent treatment without necessary of daily treatment) and decrease mortality rate (by providing continuous coagulation factor level in blood system).

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