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ISSN: 2157-7099

Journal of Cytology & Histology
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  • Research Article   
  • J Cytol Histol 2017, Vol 8(5): 482
  • DOI: 10.4172/2157-7099.1000482

The Cytomorphological Characteristics of Non-small Cell Lung Cancer are Associated with Its Radiological Features

Ryota Tanaka1*, Norihiko Sakamoto2, Hitomi Suzuki2, Keisei Tachibana1, Hidefumi Takei1, Koji Kishimoto2, Masachika Fujiwara2, Hiroshi Kamma2, Junji Shibahara2 and Haruhiko Kondo1
1Department of Surgery, School of Medicine, Kyorin University, Tokyo, Japan
2Department of Pathology, School of Medicine, Kyorin University, Tokyo, Japan
*Corresponding Author : Ryota Tanaka, Department of Surgery, School of Medicine, Kyorin University, 6-20-2, Shinkawa, Mitaka-shi, Tokyo 181-8611, Japan, Tel: +81-422-47-5511, Fax: +81-422-44-3576, Email: [email protected]

Received Date: Oct 10, 2017 / Accepted Date: Nov 04, 2017 / Published Date: Nov 12, 2017


Background: Distinguishing the histological subtype of lung cancer is extremely important because chemotherapy agents may have different chemotherapeutic effects in different histological subtypes. This study retrospectively evaluated the characteristic differences in the cytomorphological and radiological features of nonsmall cell lung cancer.
Methods: This study population included 50 lung cancer patients who were diagnosed based on bronchoscopic biopsy findings and underwent surgery from April 2011 to May 2016. Cyotological specimens (Papanicolaou’s staining) were separately analyzed by two experienced cytotechnicians. The associations between the clinicopathological data, as well as the preoperative radiological features on computed tomography (CT) and positron emission tomography (PET) and cytomorphological analyses were analyzed.
Results: Forty-five specimens were analyzed (adenocarcinoma [ADC] [n=38], squamous cell carcinomas [SQCC] [n=7]). The ADCs were cytomorphologically sub-classified as follows: acinar (n=25), solid (n=10), lepidic (n=2) and papillary (n=1). Among specimens with a solid pattern of ADC, there was a significantly greater percentage of samples with a necrotic background (50%), predominant 3D clusters (100%) and conspicuous nucleoli (80%) compared to specimens with a nonsolid pattern of ADC. The CT images of patients with solid ADC (90%) and SQCC (100%) tended to show solid nodules on CT. On PET, the maximum standardized uptake values at 120 minutes in solid ADC and SQCC were significantly higher in comparison to nonsolid ADC (12.8 ± 6.1 and 17.2 ± 7.3 versus 8.9 ± 4.4, respectively).
Conclusions: The differentiation of the cytomorphological characteristics might predict the values of radiological features, and thereby provide information that can be used when determining the treatment strategies.

Keywords: High resolution computed tomography; Positron emission tomography; Non-small cell lung cancer; Cytomorphological subtypes; Lung adenocarcinoma

Citation: Tanaka R, Sakamoto N, Suzuki H, Tachibana K, Takei H, et al. (2017) The Cytomorphological Characteristics of Non-small Cell Lung Cancer are Associated with Its Radiological Features. J Cytol Histol 8: 482. Doi: 10.4172/2157-7099.1000482

Copyright: © 2017 Tanaka R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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