alexa The Cytotoxic Effect of Polyelectrolyte Shells Coated B
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

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Research Article

The Cytotoxic Effect of Polyelectrolyte Shells Coated Bacterial Cells on Human Leukemia Cells

M. Borkowska1, M. Lyzniak2, A. Grzeczkowicz1, R. Stachowiak3, J. Kawiak1, J. Bielecki3, B. K. Budziszewska2 and L. H. Granicka1*

1Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland

2Institute of Hematologyand Transfusion Medicine, Warsaw, Poland

3Department of Applied Microbiology, Faculty of Biology, University of Warsaw, Warsaw, Poland

*Corresponding Author:
Ludomira H. Granicka
Nalecz Institute of Biocybernetics and
Biomedical Engineering
Polish Academy of Sciences
Warsaw, Poland
E-mail: [email protected]

Received Date: October 17, 2012; Accepted Date: November 09, 2012; Published Date: November 12, 2012

Citation: Borkowska M, Lyzniak M, Grzeczkowicz A, Stachowiak R, Kawiak J, et al.(2012) The Cytotoxic Effect of Polyelectrolyte Shells Coated Bacterial Cells on Human Leukemia Cells. J Nanomed Nanotechol 3:152. doi:10.4172/2157-7013.1000152

Copyright: © 2012 Borkowska M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Encapsulation of cells in polymeric shells allowing for separation of biological material from produced factors may find application in the systems for biological processes regulation. Inadequate efficiency of existing therapeutic anticancer regiments and the rise of multi-drug resistant cancer cells have required investigations into novel anticancer strategies. Enhancement of apoptosis in tumors has been suggested as a new anticancer strategy. Pathogenic microorganisms may have the role as the source of agents for apoptotic therapy.

Modified cells of Bacillus subtilis were encapsulated using layer-by-layer technique within polymeric shells for application in local anti-tumor therapy.

The applied shells were modified with incorporated fullerene derivate to ensure the layers stability and integrity.The impact of modified nano-thin shells coated bacterial cells on human leukemia cells was evaluated in vitro. It was observed that coating with applied polyelectrolyte layers with incorporated fullerenol allowed for bacterial cells functioning during the culture period and the lethal impact on eukaryotic cells was observed.

Applied membrane conformation allowing for functioning of encapsulated microorganisms may be recommended or coating shells for local anti-tumor treatment purposes.

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