alexa The Development of Cancer Genome Research and its Clini
ISSN: 2157-7420

Journal of Health & Medical Informatics
Open Access

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Review Article

The Development of Cancer Genome Research and its Clinical Opportunity brought by Next Generation Sequencing

Jun Li, Bin Wang, Hu Fang and Xu Yang*
Department of Human Medical Research, Research & Cooperation Division, BGI-Shenzhen, China
*Corresponding Author : Xu Yang, Ph.D
BGI-Shenzhen, Shenzhen 518083, China
E-mail: [email protected]
Received Novmeber 23, 2011; Accepted January 30, 2012; Published February 06, 2012
Citation: Li J, Wang B, Fang H, Yang X (2012) The Development of Cancer Genome Research and its Clinical Opportunity brought by Next Generation Sequencing. J Health Med Informat S1:002. doi:10.4172/2157-7420.S1-002
Copyright: © 2012 Li J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Cancer has been investigated due to its high mortality ever since last century. Although chemotherapy has been traditionally used for cancer patients for a long time, the obvious side effects have prevented its further application. With the progress of DNA sequencing technology, targeted therapy has been developed by affecting targeted molecules in the signaling pathways. It could act as an alternative strategy of cancer therapeutics. In this way, cancer patients could undergo fewer side effects than traditional chemotherapy. In the 21st century, next generation sequencing (NGS) technologies have emerged to dramatically promote the cancer genome research. Recent researches have shown that the rapid discoveries of mutated cancer genes by NGS are potential to revolutionize cancer therapeutics. In the future, the development of NGS technologies is hopeful to achieve personalized therapeutics in clinic.

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