alexa The Different Distribution of Hepatitis C Virus Genotypes in Eastern Black Sea Region of Turkey
ISSN: 1948-5948

Journal of Microbial & Biochemical Technology
Open Access

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Research Article

The Different Distribution of Hepatitis C Virus Genotypes in Eastern Black Sea Region of Turkey

Aziz Ramazan DILEK1*, Kazim SAHIN2, Ilkay BAHÇECI, Nursel DILEK

1Microbiology Department of Recep Tayyip Erdogan University, Medical Faculty Hospital, Rize, Turkey

2Dermatology Department of Recep Tayyip Erdogan University, Medical Faculty Hospital, Rize, Turkey

*Corresponding Author:
Aziz Ramazan DILEK
Microbiology Department of Recep
Tayyip Erdogan University
Medical Faculty Hospital, Rize, Turkey
Tel/Fax: 0090-464-2130491
E-mail: [email protected]

Received date: October 09, 2013; Accepted date: October 28, 2013; Published date: October 31, 2013

Citation: DILEK AR, SAHIN K, BAHÇECI I, DILEK N (2013) The Different Distribution of Hepatitis C Virus Genotypes in Eastern Black Sea Region of Turkey. J Microb Biochem Technol 5:092-094. doi: 10.4172/1948-5948.1000107

Copyright: © 2013 DILEK AR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

Hepatitis C virus (HCV) has infected about 170-200 million people worldwide and HCV genotypes have been related with a particular geographic distribution. The information of genotypes in chronic hepatitis C is critical for the decision of the pharmaceutical regimen, and for the therapeutic outcome. The aim of the study was determining the dispersion of hepatitis C Virus genotype in our area. The study was conducted on 42 patients who referred from various clinics infected with HCV. Serum HCV RNA levels were quantified by using the COBAS AMPLICOR HCV Monitor 2.0. An 851 bp long fragment spanning codons 63 to 347 of the RNA-dependent RNA polymerase in the NS5b part of the HCV genome was amplified. PCR amplifications were conducted in a BioRad DNA Engine using Quantitect SYBR Green PCR mix. Purified PCR products expressively sequenced with the ABI PRISM 310 Genetic Analyzer appliance utilizing DYEnamic ET Terminator Cycle Sequencing Kit. The most prevalent genotype was type 1b (90.4%) in our study. In the other types, type 3 and 4 were detected. We believe that distribution of HCV genotype in this region should be followed strictly due to difference from reports, which reported other parts of Turkey.

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