alexa The Effect of Amino-Bisphosphonate Therapy on Gingival Crevicular Fluid Alkaline Phosphatase Activity in Cancer Patients | OMICS International | Abstract
ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
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Research Article

The Effect of Amino-Bisphosphonate Therapy on Gingival Crevicular Fluid Alkaline Phosphatase Activity in Cancer Patients

Katia Rupel1, Giuseppe Perinetti1, Luca Contardo1, Giulia Ottaviani1, Margherita Gobbo1, Sara De Iudicibus2, Roberto Di Lenarda1
and Matteo Biasotto1*

1Dental Science Department, University of Trieste, Italy

2Institute for Maternal and Child health, IRCCS Burlo Garofolo, Trieste, Italy

*Corresponding Author:
Matteo Biasotto
Piazza Ospitale 134100 Trieste Italy
Tel: +390403992102
Fax: +390403992193
E-mail: [email protected]

Received Date: January 10, 2014; Accepted Date: February 04, 2014; Published Date: February 10, 2014

Citation: Rupel K, Perinetti G, Contardo L, Ottaviani G, Gobbo M, et al. (2014) The Effect of Amino-Bisphosphonate Therapy on Gingival Crevicular Fluid Alkaline Phosphatase Activity in Cancer Patients. J Mol Biomark Diagn 5:166. doi:10.4172/2155-9929.1000166

Copyright: © 2014 Rupel K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Abstract

The enzyme Alkaline Phosphatase (ALP) is considered a biomarker of bone formation and it is used for monitoring intravenous Bisphosphonate (BP) therapy. It can be measured in serum and urine, but also in Gingival Crevicular Fluid (GCF). The aim of the present study was to monitor the GCF-ALP activity fluctuations in cancer patients before and during the first six months of BP therapy, comparing them with systemic serum ALP concentrations. 33 patients and 25 controls were enrolled according to the eligibility criteria. The GCF was collected at baseline, and after every BP administration for 6 times. The total ALP activities were determined spectrophotometrically. The results show how the differences in GCF-ALP activity over time appear to be significant in the BP-taking group (p=0.003), while the differences in serum ALP in the BP-taking group and in GCF-ALP activity in the control group were not significant (p>0.05). GCF-ALP activity may thus represent a possible new biomarker for bone turnover rate evaluation in patients taking intravenous BP therapy. Up to date, this is the first study that investigates on variations of GCF-ALP activity due to changes in bone metabolism caused by intravenous nitrogen-containing BP therapy in cancer patients.

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