alexa The Effect of Biodegradable Scaffolds for Osteochondral Repair on the Immobilized Rabbit Knee
ISSN: 2161-1076

Surgery: Current Research
Open Access

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Research Article

The Effect of Biodegradable Scaffolds for Osteochondral Repair on the Immobilized Rabbit Knee

Chih-Chan Lin1,2, Nai-Jen Chang3, Ming-Long Yeh4,5, Chien-Feng Li6 and Yung-Chang Lin2*

1Laboratory Animal Center, Department of Medical Research, Chi-Mei Medical Center, 901 Zhonghua, Yongkang Dist., Tainan City 701, Taiwan

2Department of Veterinary Medicine, National Chung Hsing University, 250 KuoKuang Rd., South Dist., Taichung City 402, Taiwan

3Department of Sports Medicine, Kaohsiung Medical University, 100, Shih-Chuan 1st Rd., Kaohsiung City, Taiwan

4Department of Biomedical Engineering, National Cheng Kung University, 1 University Rd., Tainan City 701, Taiwan

5Medical Device Innovation Center, National Cheng Kung University, Tainan City 701, Taiwan

6Division of Clinical Pathology, Department of Pathology, Chi-Mei Medical Center, 901 Zhonghua Rd., Yongkang Dist., Tainan City 701, Taiwan

*Corresponding Author:
Yung-Chang Lin
Department of Veterinary Medicine
National Chung Hsing University, No.250
KuoKuang Rd., South Dist
Taichung City 402, Taiwan
E-mail: [email protected], [email protected]

Received date: December 07, 2013; Accepted date: December 30, 2013; Published date: January 07, 2014

Citation: Lin CC, Chang NJ, Yeh ML, Li CF, Lin YC (2014) The Effect of Biodegradable Scaffolds for Osteochondral Repair on the Immobilized Rabbit Knee. Surgery Curr Res 4:158. doi:10.4172/2161-1076.1000158

Copyright: © 2014 Lin CC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: An initial constrained weight-bearing period achieved via immobilization (Imm) is recommended during osteochondral regeneration to avoid tissue re-injury. However, remedying osteochondral defects with a scaffoldbased treatment and Imm intervention has yet to be studied in osteochondral defect models. Therefore, we investigated the combined outcome of short-term Imm on osteochondral defects with and without porous poly (lactic-co-glycolic acid) (PLGA) scaffold implants.

Methods: Twenty-four rabbits were divided into empty defect (ED) and PLGA-implanted (PI) groups. Each rabbit’s unilateral knee, which contained an osteochondral defect, was immobilized at full extension with a splint for 2 weeks after surgery and subsequently remobilized until sacrifice at 4 weeks or 12 weeks post surgery. The health status; gross appearance; histological analysis detailing collagen, glycosaminoglycan, and matrix metalloproteinase (MMP)- 13 expression levels; and micro-CT images of the rabbits were evaluated.

Results: At 4 weeks, the ED and PI groups both exhibited degenerative cartilage features, including an irregular joint surface, fibrous or fibrocartilage formation, decreased glycosaminoglycan (GAG) expression, and increased MMP-13 expression. However, at 12 weeks, the PI group exhibited significantly higher GAG expression, lower MMP- 13 expression, and more bony deposition matrix and trabecular bone than the ED group.

Conclusion: Our findings indicate that the short-term Imm is harmful to articular cartilage; however, PLGA grafts could provide a matrix for tissue regeneration

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