The Effect of Chemotherapy on Serum Carnitine Levels and Fatigue in Chemotherapy Naive Medical Oncology Patients: A Pilot Study. Carnitine, Chemotherapy and FatigueWolfgang M Marx1*, LaisaTeleni2, Maree Ferguson2, Euan Walpole3 and Elizabeth A Isenring1,2,4
- *Corresponding Author:
- Wolfgang Marx
Centre for Dietetics Research
School of Human Movement Studies
University of Queensland
Brisbane, Queensland, Australia
Tel: +61 418 398 446
E-mail: [email protected]
Received date: November 27, 2013; Accepted date: November 27, 2013; Published date: January 24, 2014
Citation: Marx WM, Teleni L, Ferguson M, Walpole E, Isenring EA (2014) The Effect of Chemotherapy on Serum Carnitine Levels and Fatigue in Chemotherapy Naïve Medical Oncology Patients: A Pilot Study. Carnitine, Chemotherapy and Fatigue. J Nutr Disorders Ther 4:131. doi: 10.4172/2161-0509.1000131
Copyright: © 2014 Marx WM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Fatigue, a highly prevalent side-effect of anticancer therapy, poses a significant burden on patient quality of life. Carnitine deficiency has been implicated in the development of fatigue during chemotherapy.
Methods: This pilot study aimed to evaluate the relationship between chemotherapy-related fatigue and serum carnitine (total, free- and acyl: free carnitine ratio) in 35 chemotherapy-naïve oncology patients at baseline, 6 and12 weeks.
Results: Carnitine deficiency, based on acyl: free carnitine ratio, was detected in three patients at baseline but this did not persist to the next time point. Carnitine deficiency was not detected in any other participant throughout this study and levels of carnitine were not correlated with fatigue during the study period.
Conclusion: A relationship between carnitine status and fatigue was not found at the time points measured. Further research is required to confirm these results in a larger medical oncology population.