The Effect of Chromium and Selenium Ions on Mitochondrial Trans membrane Transport of Fatty Acids in Healthy and Diabetic Rats
Tomasz Kury, Maria Milczarek and Bogdan Debski*
Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw Life Sciences University, Poland
- *Corresponding Author:
- Bogdan Debski
Department of Physiological Sciences
Faculty of Veterinary Medicine
Warsaw Life Sciences University, Poland
E-mail: [email protected]
Received date: November 14, 2013; Accepted date: February 12, 2014; Published date: February 14, 2014
Citation: Kury T, Milczarek M, Debski B (2014) The Effect of Chromium and Selenium Ions on Mitochondrial Trans membrane Transport of Fatty Acids in Healthy and Diabetic Rats. J Veterinar Sci Technol 5:159. doi:10.4172/2157-7579.1000159
Copyright: © 2014 Kury T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Essential trace elements, chromium (Cr+3) as well as selenium (Se+4) and (Se-2) exhibits stimulatory effect on β-oxidation of fatty acids, especially after supplementation with carnitine. Presented results allowed to conclude, that the trace elements ions modify the activity of the transport of fatty acids across the mitochondrial membranes. It seems that the limiting step of this process is the activity of carnitine-palmitoyl transferase-1 (CPT-1), which is responsible for transport of substrate across the external membrane. In this process selenium ions (Se+4) and (Se-2) are more active than chromium (Cr+4). In all studied combinations of ions the activity of carnitine-palmitoyl transferase -2 (CPT-2) remains almost unchanged. Only small stimulatory effect was observed in combination of Cr and Se ions, but in these variants inhibitory effect on CPT-1 occur.