The Effect of Electromagnetic Field Treatment on Recovery from Spinal Cord Injury in a Rat Model Clinical and Imaging FindingsYaron Segal1*, Lear Segal1, Ester Shohami1, Efrat Sasson2, Tamar Blumenfeld-Katzir2, Abraham Cohen3, Aharon Levy3 and Ariela Alter1
- *Corresponding Author :
- Yaron Segal
BrainQ Ltd. P.O. Box 68135
Jerusalem, 9339228, Israel
E-mail: [email protected]
Received date: March 01, 2016 Accepted date: March 21, 2016 Published date: March 28, 2016
Citation: Segal Y, Segal L, Shohami E, Sasson E, Blumenfeld-Katzir T, et al. (2016) The Effect of Electromagnetic Field Treatment on Recovery from Spinal Cord Injury in a Rat Model – Clinical and Imaging Findings. Int J Neurorehabilitation 3:203. doi: 10.4172/2376-0281.1000203
Copyright: © 2016 Segal Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Spinal cord injury (SCI) refers to spinal cord damage arising from trauma, disease or degeneration. At present, there is still no treatment for any paraplegia resulting from SCI. We have previously shown that very low intensity, low frequency, electromagnetic field treatment (VLIFE) promotes neuronal plasticity after stroke and as a result, improves clinical recovery.
Objective: In this paper we studied an innovative electromagnetic field treatment for SCI in an animal model.
Methods: SCI was caused to 20 rats by hemi crush. The animals were divided into three groups, 7 animals were not treated, two groups received VLIFE treatment for two months, 7 rats received 15.72 Hz, and 6 rats received a dedicated treatment of 26 Hz. Clinical evaluation was performed weekly, and imaging assessment monthly.
Results: Clinical performance assessed by a locomotor test, show significant clinical improvement of the neurological function following treatment with VLIFE (p < 0.05). Imaging results after two months of treatment, by MRI including DTI analysis, show that the non-treated (sham) spinal cord has not recovered, while in the treated animal the fibers of the spinal cord were preserved and rewired. VLIFE treatment has major benefits on injured spinal cord: preservation of the spinal cord from further degradation caused by the edema and internal cord scars, and rewiring of the spinal cord resulting with rehabilitation and improved clinical performance.
Conclusions: Low intensity low frequency electromagnetic field treatment may be beneficial for rehabilitation from SCI, human clinical trials are planned.