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The Effect of Erythropoietin on Total Protein Levels during Ischemia Reperfusion Injury in Rats | OMICS International | Abstract
ISSN: 2376-0281

International Journal of Neurorehabilitation
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Research Article

The Effect of Erythropoietin on Total Protein Levels during Ischemia Reperfusion Injury in Rats

Τsompos C1*, Panoulis C2, Τοutouzas K3, Ζografos G3 and Papalois A4

1Department of Obstetrics and Gynecology, Messolonghi County Hospital, Etoloakarnania, Greece

2Department of Obstetrics and Gynecology, Aretaieion Hospital, Athens University, Attiki, Greece

3Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece

4Exprerimental Research Center ELPEN Pharmaceuticals, S.A. Inc., Co., Greece

*Corresponding Author:
Tsompos Constantinos
Department of Obstetrics and Gynecology
Mesologi County Hospital, Nafpaktou street
Mesologi 30200, Etoloakarnania, Greece
Tel: 00302631360237
Fax: 00302106811215
E-mail: [email protected]

Received December 31, 2014; Accepted January 25, 2015; Published February 05, 2015

Citation: Τsompos C, Panoulis C, Τοutouzas K, Ζografos G, Papalois A (2015) The Effect of Erythropoietin on Total Protein Levels during Ischemia Reperfusion Injury in Rats. Int J Neurorehabilitation 2:146. doi:10.4172/2376-0281.1000146

Copyright: © 2015 Τsompos C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Aim: The aim of this experimental study was to examine the effect of erythropoietin on rat model and particularly in an ischemia-reperfusion (IR) protocol. The beneficial effect or non-effectiveness of that molecule was studied biochemically using blood mean total protein levels.

Materials and Methods: 40 rats of mean weight 247.7 g were used in the study. Total protein levels were measured at 60 min (groups A and C) and 120 min (groups B and D) of reperfusion. Erythropoietin was administered in groups C and D.

Results: Epo administration non-significantly decreased the predicted TP levels by 1.27% ± 1.51% (p=0.3721). Reperfusion time non-significantly increased the predicted TP levels by 1.27% +1.51% (p=0.3549). However, erythropoietin administration and reperfusion time together produced a non-significant combined effect in decreasing the predicted TP levels by 0.68% ± 2.48% (p=0.4430).

Conclusions: Erythropoietin administration interacted or not with reperfusion time has non-significant short – term decreasing effects on blood total protein levels.


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