alexa The Effect of High-Dose Simvastatin Therapy on Patients
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Research Article

The Effect of High-Dose Simvastatin Therapy on Patients with Acute Cerebral Infarction

Xiaozhu Liu1*, Huankun Liang2, Kangyan Li2, Jiali Li2, Laiqing Li2 and Licheng Zhang3

1Guizhou Institute of Technology, Guiyang, Guizhou, China

2Guangzhou Youdi Biotechnology Company, Guangzhou, Guangdong, China

3Cancer Center of The 88 Hospital of People’s Liberation Army, Tai’an, Shandong, China

*Corresponding Author:
Xiaozhu Liu
Guizhou Institute of Technology
Guiyang, 550000, Guizhou, China
Tel: +862022056980
E-mail: [email protected]

Received date: June 01, 2017; Accepted date: June 07, 2017; Published date: June 13, 2017

Citation: Liu X, Liang H, Li K, Li J, Li L, et al. (2017) The Effect of High-Dose Simvastatin Therapy on Patients with Acute Cerebral Infarction. J Clin Exp Cardiolog 8:527. doi: 10.4172/2155-9880.1000527

Copyright: © 2017 Liu X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Cerebrovascular disease (CVD) accounts for the major cause of morbidity and mortality in industrialized countries. However, effects of high-dose simvastatin therapy on patients with acute cerebral infarction still unclear. In this study, the clinical efficacy of high-dose simvastatin on patients with cerebral infarction was investigated. A total of 180 patients with acute cerebral infarction were randomized divided into control group (n=60), high-dose simvastatin (HDS) group (n=60) and low-dose simvastatin (LDS) group (n=60). Control group, HDS group and LDS group received conventional treatment, conventional treatment together with simvastatin 80 mg/d and conventional treatment as well as simvastatin 40 mg/d respectively for 3 months. Biochemical indices, neurological deficit and plaque thickness and volume were assessed and recorded after treatment. After simvastatin treatment, the plasma levels of Triglyceride, Total cholesterol, Low-density lipoprotein were significantly decreased in HDS group and LDS group, and HDS were significantly increased in HDS group and LDS group. Also, simvastatin decreased levels of IL-6 and TNF-α, two major inflammatory factors in plasma. Furthermore, improved neurological deficit were found in simvastatin treatment groups. In addition, simvastatin treatment also improved plaque states include plaque thickness and volume in HDS group and LDS group. Therefore, simvastatin could improve acute cerebral infarction and high-dose of simvastatin treatment was better than low -dose of simvastatin treatment.


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