alexa The Effect of Mycophenolate Mofetil on Graft Versus Host Disease in Cyclosporine Induced Thrombotic Microangiopathy after Allogeneic Hematopoietic Stem Cell Transplantation
ISSN: 2572-4916

Journal of Bone Research
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Case Report

The Effect of Mycophenolate Mofetil on Graft Versus Host Disease in Cyclosporine Induced Thrombotic Microangiopathy after Allogeneic Hematopoietic Stem Cell Transplantation

Niparuck P1*, Pukiat S1, Puavilai T1, Ativitavas T2 and Ungkanont A1
1Division of Hematology, Medicine department, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
2Division of Oncology, Medicine department, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Corresponding Author : Pimjai Niparuck
Clinical Instructor, Division of Hematology Medicine
department, Ramathibodi Hospital Mahidol University
Rama VI Road Bangkok 10400, Thailand
Tel:
+662-201-1392, +662-201-2373
Fax: +662-201-1392
E-mail:
[email protected]
Received: January 19, 2016 Accepted: February 09, 2016 Published: February 15, 2016
Citation: Niparuck P, Pukiat S, Puavilai T, Ativitavas T, Ungkanont A (2016) The Effect of Mycophenolate Mofetil on Graft Versus Host Disease in Cyclosporine Induced Thrombotic Microangiopathy after Allogeneic Hematopoietic Stem Cell Transplantation. J Bone Res 4:165.
Copyright: © 2016 Niparuck P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Calcineurin inhibitor induced thrombotic microangiopathy (TMA) is a serious complication in hematopoietic stem cell transplantation (HSCT). Mycophenolate mofetil (MMF) is a safe immunosuppressive drug that can be used for prophylaxis of primary graft versus host disease (GVHD) after developing TMA. In this study, our two patients received CellCept® after developing cyclosporine induced TMA. Acute GVHD (skin, oral and liver) was found in both patients, nevertheless, the GVHD was not severe and can be controlled with low dose prednisolone. Therefore, MMF is an optional immunosuppressant for GVHD prophylaxis in the transplant patient diagnosed with calcineurin or m-TOR inhibitors induced TMA.

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