The Effect of Oral Supplementation of Vitamin D3 on Serum Levels of Vitamin D: A Review
- Corresponding Author:
- Marianne Berwick
Department of Internal Medicine and Dermatology
University of New Mexico, Albuquerque, NM 87131, USA
E-mail: [email protected]
Received Date: December 29, 2013; Accepted Date: February 10, 2014; Published Date: February 12, 2014
Citation: Jarrett F, Ducasa GM, Buller DB, Berwick M (2014) The Effect of Oral Supplementation of Vitamin D3 on Serum Levels of Vitamin D: A Review. Epidemiol 4:148. doi:10.4172/2161-1165.1000148
Copyright: © 2014 Jarrett F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Due to the strong interest in the role of vitamin D in health, we tried to find data to illustrate the relationship between oral supplementation and change in serum levels of vitamin D. We reviewed the literature of randomized, placebo-controlled trials of oral supplementation and serum levels of vitamin D through 2014. We found 25 informative studies which showed a significant dose-response between oral supplementation and serum levels of vitamin D with an r2 of 0.61.These data are consistent with single studies and meta-analyses.In conclusion, the data show a consistent relationship that appears to be independent of multiple confounders.