alexa The Effect of Plaque Removal on Pressure Drop and Flow
ISSN: 0974-8369

Biology and Medicine
Open Access

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Research Article

The Effect of Plaque Removal on Pressure Drop and Flow Rate through an Idealized Stenotic Lesion

Brian D. Plourde1, Lauren J. Vallez1, Biyuan Sun1, John P. Abraham1* and Cezar S. Staniloe2

1University of St. Thomas, School of Engineering, 2115 Summit Ave, St. Paul and Minneapolis, Minnesota 55105-1079, United States

2NYU Langone Medical Center, 333 East 38th St, New York 10016, United States

*Corresponding Author:
John P. Abraham
University of St. Thomas
School of Engineering
2115 Summit Ave, St. Paul and Minneapolis
Minnesota 55105-1079, United States
Tel: 651-962-5766
E-mail: [email protected]

Received date: December 07, 2015; Accepted date: December 15, 2015; Published date: December 21, 2015

Citation: Plourde BD, Vallez LJ, Sun B, Abraham JP, Staniloe CS (2015) The Effect of Plaque Removal on Pressure Drop and Flow Rate through an Idealized Stenotic Lesion. Biol Med (Aligarh) 8:261. doi:10.4172/0974-8369.1000261

Copyright: © Plourde, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Numerical calculations have been performed to quantify the importance of plaque removal on blood flow. The artery under consideration is the popliteal artery which is susceptible to plaque lesions. An orbital artherectomy device was used to partially remove a calcified plaque layer. Measurements taken before and after the treatment were used in idealized calculations and pressure losses through the lesion were determined. It was found that the removal of plaque by orbital atherectomy increases the blood flowrate through the artery. At the same time, there is a major reduction of pressure loss through the lesion. After treatment, the systolic pressure drop was 2.5 times less than prior to treatment. The cycle-averaged pressure drop was improved by a factor of 3.5. The results are similar for a wide range of plaque lesion lengths (from 3 mm to 18 mm). A deeper investigation into the source of pressure loss reveals that the majority of the loss is confined to the entrance of the lesion and is caused by flow acceleration (and later deceleration) rather than by friction. The calculations were repeated with three increasingly complex numerical methods (steady laminar, unsteady laminar, and unsteady transitional). It was found that all methods were in good agreement so that more computationally expensive techniques are not required in order to obtain accurate results. The results of the simulation were compared with clinical pressure measurements before and after treatment. The two results were found to be in good agreement.

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