alexa The Effect of Prenatal Exposure to Nicotine versus Thiocyanate on Pituitary-Testicular Axis of Juvenile Albino Rats: A Comparative Histological and Electron Microscopic Study
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

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Research Article

The Effect of Prenatal Exposure to Nicotine versus Thiocyanate on Pituitary-Testicular Axis of Juvenile Albino Rats: A Comparative Histological and Electron Microscopic Study

Ahmed SF1 and Abu Elfadl SG2*
1Departments of Histology, Faculty of Medicine, Assiut University, Asyut, Al Hamraa Ath Thaneyah, Qesm Than Asyut, Assiut Governorate, Egypt
2Departments of Histology, Faculty of Medicine, Cairo University Rd, Oula, Giza, Egypt
*Corresponding Author : Abu Elfadl SG
Departments of Histology, Faculty of Medicine
Cairo University Rd, Oula, Giza, Egypt
Tel: 00201125285784
Fax: 0020882332278
E-mail: [email protected]
Received November 18, 2015; Accepted February 01, 2016; Published February 03, 2016
Citation: Ahmed SF, Elfadl SGA (2016) The Effect of Prenatal Exposure to Nicotine versus Thiocyanate on Pituitary-Testicular Axis of Juvenile Albino Rats: A Comparative Histological and Electron Microscopic Study. J Cytol Histol S5:002. doi:10.4172/2157-7099.S5-002
Copyright: © 2016 Ahmed SF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Cigarette smoking prevalence is still increasing in the developing world especially among men mainly in central Asia, east Europe and Africa. Furthermore, maternal cigarette smoking during pregnancy has multiple deleterious effects on the offspring, which may persist into adulthood. The present work aims at clarifying whether the prenatal exposure to either nicotine or thiocyanate could be the responsible factor in induction of the possible effect of smoking on spermatogenesis and the cytoarchitecture of the testis and hence influencing the male fertility later on. Twenty pregnant rats were randomly divided into four groups from gestational day 4. Groups Ia and b served as control. Group II animals were injected with nicotine (6 mg/kg/day) subcutaneously as a single dose. Group III Animals were treated with oral potassium thiocyanate (25 mg/rat/day) as a single dose through gastric gavages. Five male litters from each group (one/each pregnant rat) were sacrificed at the age of 1 month. Pituitary and testicular tissue samples were subjected to histological and electron microscopic study. The counts of different cells of seminiferous tubules were statistically analyzed for significance. Results revealed apoptotic changes at the subcellular level of the pituitary gonadotrophs and different spermatogenic and Sertoli cells of the testis. The number of Sertoli and different spermatogenic cells- rather than spermatogonia- showed a very highly significant decrease in the nicotine treated group in comparison to the control. The dense cells revealed a very highly significant increase in the nicotine treated group. In conclusion, the results of the present study were more consistent with a suggested dual effect of nicotine on the pituitary-testicular axis rather than a purely direct effect on the testis. On the other hand, thiocyanate induced subcellular effect on the testicular histology with minimal affection of gonadotrophs.

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