The Effect of Pre-operative Oral Clonidine or Gabapentin on Post-operative Pain intensity, Morphine Consumption and Post-operative Nausea and Vomiting in Patients Who Undergone Thyroidectomy: A Double-blind Placebo-control Study
Seyed Mojtaba Marashi, Ali Akbar Morabi, Mohammad Hossein Ghafari, Omid Azimaraghi and Ali Movafegh*
Department of anesthesiology and critical care, Dr. Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
- *Corresponding Author:
- Ali Movafegh M.D
Professor, Department of anesthesiology and critical care
Dr. Ali Shariati Hospital
Jalal Al Ahmad Street, Tehran 1411713135, Iran
Tel : +98-912-3021389
Fax : +98-21-88220032
E-mail: [email protected]
Received date: March 20, 2012; Accepted date: April 17, 2012; Published date: April 20, 2012
Citation: Marashi SM, Morabi AA, Ghafari MH, Azimaraghi O,Movafegh A (2012) The Effect of Pre-operative Oral Clonidine or Gabapentin on Post-operative Pain intensity, Morphine Consumption and Post-operative Nausea and Vomiting in Patients Who Undergone Thyroidectomy: A Double-blind Placebo-control Study. J Anesth Clin Res 3:206 doi: 10.4172/2155-6148.1000206
Copyright: © 2012 Marashi SM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: This prospective, randomized, double-blind study evaluated the effect of clonidine and gabapentin premedication on postoperative pain intensity, morphine consumption, nausea and vomiting. Methods: Sixty-six ASA I-II patients, aged 20 to 55 were randomly allocated to orally receive either clonidine 0.2 mg (group C,n=22), placebo (group P,n=22) or gabapentin 900 mg (group G, n=22) two hours before operation. Postoperative visual analog scale for pain (VAS), nausea and vomiting were measured in the recovery room and 2,6,12 and 24 hours following the surgery as well. Results: The patients’ characteristics were alike in three groups. The VAS pain scores at measured times were significantly lower in the clonidine (3.4 ± 0.9, 4.2 ± 0.75, 4.8 ± 1.0, 4.9 ± 1.3, 3.3 ± 0.6) and gabapentin groups (3.1 ± 0.6, 4.1 ± 1.0, 3.6 ± 0.7, 4.7 ± 0.8, 3.5 ± 0.7) than in the placebo group (5.1 ± 1.6; 6.5 ± 1.5; 5.9 ± 0.9; 5.5 ± 0.8, 3.5 ± 0.7, (repeated-measures ANOVA, between-subjects effects, P<0.001) The post-operative morphine consumption in gabapentin group (18.3 ± 15.6 mg) was significantly less than clonidine (47.1 ± 29.1 mg, P=0.02) and placebo groups (65.7 ± 31.1mg, P<0.001). The incidence of PONV in the first 24 hour after surgery was significantly more in clonidine (40.9%) than gabapentin (9.1%%) and placebo (9.1%%) groups (P<0.01). Conclusion: Oral premedication with gabapentin or clonidine significantly decreases the post-operative pain and morphine consumption, without any decrease in PONV.