The Effect of Prostaglandin Therapy on Ankle Brachial Index in Non- Reconstructable Symptomatic Peripheral Artery Disease Patients- Retrospective AnalysisSandeep Mahapatra*, Pinjala Ramakrishna, Puneeth Joopalli and Mujtaba hussain Naqvi Syed
Nizam's Institute of Medical Sciences, Hyderabad, Telengana India
- *Corresponding Author:
- Sandeep Mahapatra
Nizam's Institute of Medical Sciences
Tel: +91 9948769761
E-mail: [email protected]
Received Date: September 09, 2015; Accepted Date: September 26, 2015; Published Date: September 30, 2015
Citation: Mahapatra S, Ramakrishna P, Joopalli P, Naqvi Syed M (2015) The Effect of Prostaglandin Therapy on Ankle Brachial Index in Non- Reconstructable Symptomatic Peripheral Artery Disease Patients- Retrospective Analysis. J Vasc Med Surg 3:222. doi: 10.4172/2329-6925.1000222
Copyright: © 2015 Mahapatra S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Prostaglandin E1 has been reported to benefit patients with significant peripheral vascular disease
and limb threatening ischemia. The present retrospective study attempts to assess the effect of Prostaglandin E1 on
ankle brachial index in non reconstructable symptomatic peripheral artery disease patients.
Objectives: To study the effect of Prostaglandin E1 on ankle brachial index in non reconstructable symptomatic
peripheral artery disease patients.
Methods: Case records of 40 patients who had completed at least six cycles of injection were obtained from
medical records of vascular surgery. The demographic data and the ankle brachial index of these patients were
recorded at baseline and at the end of six cycles of the drug.
Results: The average ABI of both the limbs changed significantly from baseline to the end of study after six
cycles of Prostaglandin E1 injection (p<0.05). There was significant increase in Ankle brachial index for the
symptomatic limb from baseline whereas the contra lateral limb did not show a significant change. There was a
significant increase in Ankle brachial index of both limbs as well as the average Ankle brachial index in the patients
without any co-morbidities conditions than those with the presence of co-morbidities.
Conclusion: Prostaglandin E1 therapy increases the ankle brachial index in symptomatic limb of patients with
non reconstructable symptomatic peripheral artery disease patients.