alexa The Effects of Angiotensin-Converting-Enzyme Inhibitor
ISSN: 2319-9865

Research & Reviews: Journal of Medical and Health Sciences
Open Access

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Editorial

The Effects of Angiotensin-Converting-Enzyme Inhibitor (Captopril) on Gentamicin Nephrotoxicity in Rats.

Zainab M Al-Attiyah1, Imad M Al-Ani2*, Humam N Abdul-Kareem3 and Enas I Matloup4

1 Department of Biology, College of Science, Al-Mustansiriah University, Baghdad, Iraq.

2 Department of BMS, Kulliyyah of Medicine, International Islamic University Malaysia, Kuantan, Malaysia.

3 Al-Mua’alemeen Primary Health Centre, Ministry of Health, Baghdad, Iraq.

4Al-Yarmouk Teaching Hospital, Ministry of Health, Baghdad, Iraq.

*Corresponding Author:
Imad M Al-Ani
Department of BMS
Kulliyyah of Medicine
International Islamic University
Malaysia,P.O. Box 141, 25710 Kuantan
Pahang, Malaysia.
Tel. +60179776014

Received: 30/04/2013 Accepted: 10/08/2013 Revised: 16/07/2013

 

Abstract

This study was designed to investigate the effects of captopril on gentamicin nephrotoxicity. Six groups of male Wister rats “15 rats each” were used. Group “C”, was given 1ml of normal saline, group “G25” was injected with a single dose of GM (25mg/Kg/day), group “G50” was injected with a single dose of GM (50mg/Kg/day), group “Cp2” was given a single oral dose of captopril (2mg/day), group “Cp2+G25” was injected with a single dose of GM (25mg/Kg/day) and a single oral dose of captopril (2mg/day), group “Cp2+G50” was injected with a single dose of GM (50mg/Kg/day) and a single oral dose of captopril (2mg/day). Treatment continued daily for 15 days; analysis was performed on days 5, 10 and 15. Blood urea nitrogen and serum creatinine levels were significantly elevated on the 5th day and continued to increase throughout the duration of the experiment; there was a gradual decrease in the creatinine clearance level, starting from the 5th day of treatment, which was related to the duration and dosage used in the GM treated rats. The administration of captopril progressively reduced the functional deteriorations induced by GM. It is concluded that captopril reduces GM-induced renal damage, suggesting protective effect of captopril against GM nephrotoxicity.

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