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ISSN: 2155-9562

Journal of Neurology & Neurophysiology
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Case Report

The Effects of Sub-Clinical EEG on Cognition; A Case of Two Patients with JME

Nasur Iqbal1*, Helen L Caswell2 and Susan Duncan3

1Department of Clinical Psychology, North Manchester General Hospital, Delaunay’s Road, Crumpsall, Manchester, M8 5RB, UK

2Department of Clinical Neuropsychology, Hope Hospital, Stott Lane, Salford, Manchester, M6 8HD, UK

3Epilepsy Service, Ward 31, Department of Clinical Neurosciences, Western General Hospital, Edinburgh, EH4 2XU, UK

Corresponding Author:
Nasur Iqbal
Department of Clinical Psychology
North Manchester General Hospital
Delaunay’s Road, Crumpsall, Manchester, M8 5RB, UK
Tel: 0161 720 2810
E-mail: [email protected]

Received date: April 10, 2014; Accepted dat: May 22, 2014; Published date: May 27, 2014

Citation: Iqbal N, Caswell HL, Duncan S (2014) The Effects of Sub-Clinical EEG on Cognition; A Case of Two Patients with JME. J Neurol Neurophysiol 5:210. doi:10.4172/2155-9562.1000210

Copyright: © 2014 Iqbal N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


It is increasingly becoming apparent that patients with Juvenile Myoclonic Epilepsy (JME) experience difficulties
with various aspects of cognition. Studies that have attempted to find specific seizure-related factors contributing to
and predicting cognitive dysfunction have provided conflicting and inconclusive results. In this brief paper we aimed
to discuss the nature and context of sub-clinical EEG activity on cognition in JME using two individual cases. It
seems that the potential ‘mechanism’ for cognitive impairments in JME is unlikely to be solely attributable to the
effects of paroxysmal discharges and further research is required to clarify the longer term , cumulative effects of a
range of factors that may help to explain such deficits in cognitive functioning.


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