alexa The Effects of Synthesized Rhenium Acetylsalicylate Compounds on Human Astrocytoma Cell Lines | OMICS International| Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Research Article   
  • J Cancer Sci Ther/Vol.10.1 027(2018),
  • DOI: 10.4172/1948-5956.1000512

The Effects of Synthesized Rhenium Acetylsalicylate Compounds on Human Astrocytoma Cell Lines

Hirendra N. Banerjee1*, Deidre Vaughan1, Ava Boston1, Gabriel Thorne1, Gloria Payne1, Josiah Sampson1, Vinod Manglik1, Pola Olczak2, Brent V. Powell2, Angela Winstead2, Roosevelt Shaw2 and Santosh K Mandal2*
1Department of Natural, Pharmacy and Health Sciences, Elizabeth City State University, University of North Carolina, Elizabeth City, NC, USA
2Department of Chemistry, Morgan State University, Baltimore, MD, USA
*Corresponding Author (s) : Hirendra N. Banerjee, Department of Natural, Pharmacy and Health Sciences, Elizabeth City State University, University of North Carolina, Elizabeth City, NC, USA, Tel: 2523353241, Email: [email protected]
Santosh K Mandal, Department of Chemistry, Morgan State University, Baltimore, MD, USA, Tel: 4438851665, Email: [email protected]

Received Date: Jan 03, 2018 / Accepted Date: Feb 22, 2018 / Published Date: Feb 26, 2018

Abstract

Purpose: Because of the scarcity of suitable brain cancer drugs, researchers are frantically trying to discover novel and highly potent drugs free of side effects and drug-resistance. Rhenium compounds are known to be nontoxic and exhibit no drug resistance. For that reason, we have developed a series of novel rhenium acetylsalicylato (RAC or ASP) complexes to test their cytotoxicity on brain cancer cells. Also we have attempted to explore the DNA binding properties of these compounds because many drugs either directly or indirectly bind to DNA. Methods: We have treated the RAC series compounds on human astrocytoma brain cancer cell lines and rat normal brain astrocyte cells and determined the efficacy of these complexes through in vitro cytotoxicity assay. We carried out the DNA-binding study through UV titrations of a RAC compound with DNA. Also we attempted to determine the planarity of the polypyridyl ligands of the RAC series compounds using DFT calculations. Results: RAC6 is more potent than any other RAC series compounds on HTB-12 human astrocytoma cancer cells as well as on Glioblastoma Multiforme D54 cell lines. In fact, The IC-50 value of RAC6 on HTB-12 cancer cells is approximately 2 μM. As expected, the RAC series compounds were not active on normal cells. The DFT calculations on the RAC series compounds were done and suggest that the polypyridyl ligands in the complexes are planar. The UV-titrations of RAC9 with DNA were carried out. It suggests that RAC9 and possibly all RAC series compounds bind to minor grooves of the DNA. Conclusion: Because of the very low activity of RAC6 on normal cells and low IC50 value of on astrocytoma (HTB-12) cell lines, it is possible that RAC6 and its derivatives may potentially find application in the treatment of brain cancers. The DFT calculations and UV titrations suggest that RAC series compounds either bind to DNA intercalatively or minor grooves of the DNA or both. However, it is highly premature to make any definite statement in the absence of other techniques.

Keywords: Astrocytoma; Rhenium; Cytotoxicity; DNA-binding

Citation: Vaughan D, Boston A, Thorne G, Payne G, Rousch J, et al. (2018) The Effects of Synthesized Rhenium Acetylsalicylate Compounds on Human Astrocytoma Cell Lines. J Cancer Sci Ther 10: 027-030. Doi: 10.4172/1948-5956.1000512

Copyright: © 2018 Vaughan D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Recommended Conferences
Article Usage
  • Total views: 2089
  • [From(publication date): 0-2018 - Jan 25, 2020]
  • Breakdown by view type
  • HTML page views: 2000
  • PDF downloads: 89
Top