alexa The Effects of Tamsulosin Dose Escalation in Benign Prostate Hyperplasia Patients with Lower Urinary Tract Symptoms | OMICS International | Abstract
ISSN: 2168-9857

Medical & Surgical Urology
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Research Article

The Effects of Tamsulosin Dose Escalation in Benign Prostate Hyperplasia Patients with Lower Urinary Tract Symptoms

Park JS, Lee SW, Choi HY and Moon HS*

Department of Urology, Hanyang University College of Medicine, Seoul, Korea

*Corresponding Author:
Hong Sang Moon
M.D, Department of Urology, Hanyang University Guri Hospital
249-1,Gyomun-dong, Guri 471-701, Korea
Tel: +82-31-560-2374
Fax: +82-31-560-2372
E-mail: [email protected]

Received date: December 09, 2011; Accepted date: January 09, 2012; Published date: January 11, 2012

Citation: Park JS, Lee SW, Choi HY, Moon HS (2012) The Effects of Tamsulosin Dose Escalation in Benign Prostate Hyperplasia Patients with Lower Urinary Tract Symptoms. Medical & Surgical Urology S1:001. doi:10.4172/2168-9857.S1-001

Copyright: © 2012 Park JS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Purpose: To investigate the efficacy and adverse effects of escalating the dose of tamsulosin in Korean benign prostate hyperplasia (BPH) patients with lower urinary tract symptoms (LUTS).

Materials & methods: From March, 2010 to February, 2011, we prospectively enrolled 120 BPH patients who complained of LUTS. We evaluated the prostate specific antigen (PSA) levels, transrectal ultrasonograms (TRUS), International Prostate Symptom Scores (IPSS), International Index of Erectile Dysfunction Questionnaire-5 (IIEF-5) responses, uroflowmetry measurements and post-voided residuals (PVR) of these patients. At first, tamsulosin 0.2 mg was prescribed for 8 weeks. After 8 weeks, we prescribed tamsulosin 0.4 mg for a further 8 weeks to those patients who had not responded to tamsulosin 0.2 mg. After another 8 weeks we re-evaluated the variables, and assessed side effects. Patients prescribed tamsulosin 0.4 mg were divided into two groups; those whose total IPSS were reduced by more than 3 were assigned to the responder group (n=31), those whose total IPSS were reduced by less than 3 were assigned to the non-responder group (n=29). We then compared the variables and frequencies of adverse effects in the two groups.

Results: 60 patients completed the study. Mean age, prostate volume and PSA were 67.3±7.9 years, 31.0±7.7 ml and 1.8±2.3 ng/ml, respectively. Baseline prostate volume, maximal urine flow rate and IPSS score were higher in the responder group (p<0.05). There was no significant difference in baseline PVR or IIEF-5 between the two groups. Maximal urine flow rate increased in both groups but PVR did not improve in the non-responder group, and IIEF-5 scores decreased slightly in the non-responder group but not in the responder group. Numbers of adverse effects such as orthostatic hypotension, ejaculatory dysfunction, erectile dysfunction, dizziness and gastrointestinal discomfort were not significantly different in the two group (n=5 vs. 8, p=0.430).

Conclusions: Dose escalation of tamsulosin is effective in improving the urinary symptoms of patients with large prostate volumes and high IPSS scores. The incidence of adverse effects is unaffected by tamsulosin dose escalation.

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