alexa The Efficacy of Prebiotic (β-Glucan) as a Feed Additive against Toxicity of Aflatoxin B1 in Common Carp, Cyprinus Carpio L.
ISSN: 2155-9546

Journal of Aquaculture Research & Development
Open Access

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Research Article

The Efficacy of Prebiotic (β-Glucan) as a Feed Additive against Toxicity of Aflatoxin B1 in Common Carp, Cyprinus Carpio L.

Jamal K Al-Faragi*

Department of Pathology, College of Veterinary Medicine, University of Baghdad, Iraq

*Corresponding Author:
Jamal K Al-Faragi
Department of Pathology
College of Veterinary Medicine
University of Baghdad, Iraq
Tel: 1 510 663 7000
E-mail: [email protected]

Received Date: March 21, 2014; Accepted Date: May 28, 2014; Published Date: June 18, 2014

Citation: Al-Faragi JK (2014) The Efficacy of Prebiotic (ß-Glucan) as a Feed Additive against Toxicity of Aflatoxin B1 in Common Carp, Cyprinus Carpio L. J Aquac Res Development 5:240 doi: 10.4172/2155-9546.1000240

Copyright: © 2014 Al-Faragi JK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

This study was undertaken to investigate the adverse effects of aflatoxin B1 (AFB1) on common carp (Cyprinus carpio L) and detoxifying these drastic effects by using prebiotics (β-glucan). A total of six treatments were used, including a control diet (G1) that had different combinations of AFB1 and/or 1% β-glucan. This included a diet with only β-glucan (G2), 4 mg AFB1 kg dw-1 diet with β-glucan (G3) or without (G5) and 6 mg AFB1 kg dw-1 diet with β-glucan (G4) or without (G6).These diets were offered 6 days a week at 3% daily of actual biomass in fiberglass aquaria in duplicate (2 aquaria treatment-1) for 60 days. Several endpoints at different levels of biological organisations were evaluated. These included DNA damage (using comet assay), haematological parameters, histopathological changes of the liver and kidney were also examined and growth performance. Results revealed significantly increase (P<0.05) of DNA damage in AFB1 groups (G5 and G6) compared to AFB1 plus β-glucan groups (G3 and G4). The haematological parameters showed significant differences between AFB1 groups (G5 and G6) and AFB1 plus β-glucan groups (G3 and G4). Histopathological changes revealed damage to liver and kidney tissues in AFB1 groups. Different levels of AFB1 significantly (P<0.05) affect the final average of fish weight in G5 and G6 compared to G3 and G4. Interestingly specific growth rate (%) of fish was lowered in AFB1 groups (G5 and G6) compared to AFB1 plus 1% β-glucan groups (G3 and G4). In conclusion, β-glucan, found to be a successful agent protected against the genotoxicity induced by AFB1 and effectively alleviate lesions of AFB1. Therefore, obtained results recommended adding 1% β-glucan as fish feed additives.

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