alexa The Emerging Role of Sirtuin 1,-3 and -4 in Glucose and Lipid Metabolism and in Diabetes Mellitus
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
Open Access

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Review Article

The Emerging Role of Sirtuin 1,-3 and -4 in Glucose and Lipid Metabolism and in Diabetes Mellitus

Emin Murat Akbas1, Levent Demirtas2, Aydın Guclu3, Fatih Mehmet Erdur4, Fatih Ozcicek2 and Kultigin Turkmen5*

1Department of Internal Medicine, Division of Endocrinology, Erzincan University, Erzincan,Turkey

2Department of Internal Medicine, Erzincan University, Erzincan, Turkey

3Division of Nephrology, Kırsehir Training and Research Hospital, Kırsehir, Turkey

4Division of Nephrology, Meram School of Medicine, NE University, Erzincan, Turkey

5Department of Internal Medicine, Division of Nephrology, Erzincan University, Erzincan, Turkey

Corresponding Author:
Kultigin Turkmen, M.D
Associate Prof, Head, Division of Nephrology
Department of Internal Medicine
Erzincan University 24000, Erzincan, Turkey
Tel: 905384927877
E-mail: [email protected]

Received Date: December 29, 2013; Accepted Date: February 17, 2014; Published Date: February 20, 2014

Citation: Akbas EM, Demirtas L, Guclu A, Erdur FM, Ozcicek F, et al. (2014) The Emerging Role of Sirtuin 1,-3 and -4 in Glucose and Lipid Metabolism and in Diabetes Mellitus. J Mol Genet Med S1:018. doi:10.4172/1747-0862.S1-018

Copyright: © 2014 Akbas EM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Diabetes mellitus has been accepted as an epidemic worldwide during the last two decades. Despite the diagnostic tools and therapeutic approaches, the pathophysiology of this metabolic disorder and cellular defensive mechanisms remain mysterious. The maintenance of cellular homeostasis requires well-organized network between glucose, amino acid and lipid metabolism. Sirtuins are a group of nicotinamide adenine dinucleotide dependent proteins that are involved in cellular homeostasis by their deacetylating activity. Among them, sirtuin 1,-3 and -4 have been the most extensively explored. In the present review, we aimed to discuss the role of associated sirtuins in glucose and lipid metabolism and in the pathogenesis and treatment of diabetes mellitus.

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