alexa The Emerging Role of Stem/Progenitor Cells in Pulmonary Vascular Disease | OMICS International | Abstract
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Review Article

The Emerging Role of Stem/Progenitor Cells in Pulmonary Vascular Disease

Saima Rajabali1, Duncan J. Stewart2, Shirley H. J. Mei2 and Bernard Thébaud1*
1Department of Pediatrics, Women and Children Health Research Institute, Cardiovascular Research Center, University of Alberta, Edmonton, Canada
2Ottawa Health Research Institute, The Ottawa Hospital, Ottawa, Canada
Corresponding Author : Bernard Thébaud MD, PhD
3-020H Katz Centre for Pharmacy and Health Research
University of Alberta, Edmonton
Alberta, T6G 2S2, Canada
Tel: (780) 492-7130
Fax: (780) 492-9753
E-mail: [email protected]
Received February 02, 2012; Accepted May 04, 2012; Published June 15, 2012
Citation: Rajabali S, Stewart DJ, Mei SHJ, Thébaud B (2012) The Emerging Role of Stem/Progenitor Cells in Pulmonary Vascular Disease. J Clin Exp Cardiolog S8:004. doi:10.4172/2155-9880.S8-004
Copyright: © 2012 Rajabali S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Pulmonary hypertension is a severe disease characterized by small pulmonary artery obstruction from vascular proliferation and remodeling leading to elevated mean pulmonary arterial pressure, increased pulmonary vascular resistance, right ventricular failure and death. Current treatments include prostacyclin analogs, endothelin receptor antagonists and phosphodiesterase type 5 inhibitors, which largely address mechanisms of endothelial dysfunction that were identified over 2 decades ago. Despite advances in understanding the disease mechanisms and the development of new pharmacological therapies, the prognosis of pulmonary hypertension remains poor. Recent advances in stem cell biology have unraveled the potential of stem/progenitor cells to repair damaged organs and offer the possibility for cell-based treatment for intractable diseases. This review summarizes the emerging role of stem/progenitor cells in the pathophysiology and the treatment of pulmonary hypertension.

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