The Endothelial Cell Secretome as a Factor of Endothelium Reparation: The Role of MicroparticlesAlexander E Berezin*
Consultant of Therapeutic Unit, Private Hospital “Vita-Center”, Zaporozhye, Ukraine
- *Corresponding Author:
- Alexander E Berezin
- MD, PhD, Consultant of Therapeutic Unit
Private Hospital “Vita-Center” and Consultant of Therapeutic Unit
Department of Internal Medicine, Medical University, Zaporozhye, Ukraine
Fax: 00202 33032557
E-mail: [email protected]
Received date: December 06, 2016; Accepted date: December 20, 2016; Published date: December 27, 2016
Citation: Berezin AE (2016) The Endothelial Cell Secretome as a Factor of Endothelium Reparation: The Role of Microparticles. J Metabolic Synd 5:218. doi: 10.4172/ 2167-0943.1000218
Copyright: © 2016 Berezin AE. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The secretome is considered a combination of factors produced by cells due to abundant spectrum of autocrine/ paracrine triggers. All these actively synthetizing and secreting factors include proteins, adhesion and intercellular signal molecules, peptides, lipids, free DNAs, microRNAs, and microparticles (MPs). The components of secretome mutually may interact and thereby modify the MPs’ structure and functionality. As a result, communicative ability of endothelial cell derived MPs may sufficiently impaire. Subsequently, cross talk between some components of secretome might modulate delivering cargos of MPs and their regenerative and proliferative capabilities via intercellular signaling networks. The aim of the review is to discuss the effect of various components of secretome on MP-dependent effects on endothelium.