alexa The Evaluation of Choroidal Vascular Changes Associated
ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
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Research Article

The Evaluation of Choroidal Vascular Changes Associated with Vascular Dysregulation in Patients with Multiple Sclerosis Using Enhanced Depth Imaging Optical Coherence Tomography

Omer Karti1*, Ziya Ayhan2, Eyyup Karahan3, Dilek Top Karti4, Mahmut Kaya2, Aslı Koskderelioglu4, Muteşem Gedizlioglu4, Mehmet Ozgur Zengin1 and Tuncay Kusbeci1
1Department of Ophthalmology, Bozyaka Training and Research Hospital, Izmir, Turkey
2Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey
3Department of Ophthalmology, Sifa University, Izmir, Turkey
4Department of Neurology, Bozyaka Training and Research Hospital, Izmir, Turkey
*Corresponding Author : Omer Karti, MD
Çatalkaya Mah, Gunaydın sok
Zümrütevler Sitesi, No:1/8 Narlıdere, Turkey
Tel: 90 505 598 56 85
E-mail: [email protected]
Received date: January 18, 2016; Accepted date: March 26, 2016; Published date: March 29, 2016
Citation: Karti O, Ayhan Z, Karahan E, Karti DT, Kaya M, et al. (2016) The Evaluation of Choroidal Vascular Changes Associated with Vascular Dysregulation in Patients with Multiple Sclerosis Using Enhanced Depth Imaging Optical Coherence Tomography. J Clin Exp Ophthalmol 7:534. doi:10.4172/2155-9570.1000534
Copyright: © 2016 Karti O, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Purpose: To evaluate the choroidal thickness (CT) in patients with Multiple Sclerosis (MS) using enhanced depth imaging optical coherence tomography (EDI-OCT) and comparing it with healthy subjects. Material/Methods: Sixty-four eyes of 32 patients with MS (22 women, 10 men, mean age: 37.5 ± 8.21 years) were enrolled in this study. Their choroidal thickness was measured using EDI-OCT, and compared with healthy subjects. CT was measured at fovea and at four extrafoveal points. Results: The mean subfoveal choroidal thickness was 327.01 ± 64.60 μm in MS patients and 365.3 ± 99.14 μm in controls ( p=0.019 ). Significant differences were found at points temporal 500 μm, temporal 1000 μm and nasal 500 μm to the fovea between patients and control group ( p=0.018, 0.003 and 0.03, respectively). Conclusions: Patients with MS had thinner choroids when compared to normal subjects. The decrease in mean choroidal thickness in MS patients compared to controls may be related to vascular dysregulation or inflammatory pathology of MS. Further prospective studies are needed to evaluate the choroidal thickness in MS patients.

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